HEPATOID ADENOCARCINOMA - A DISTINCTIVE HISTOLOGICAL SUBTYPE OF ALPHA-FETOPROTEIN-PRODUCING LUNG-CARCINOMA
HEPATOID ADENOCARCINOMA - A DISTINCTIVE HISTOLOGICAL SUBTYPE OF ALPHA-FETOPROTEIN-PRODUCING LUNG-CARCINOMA
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DOI：
10.1007/bf01600112
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发表时间：
1990-05-01
期刊：
影响因子：
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通讯作者：
MIZUNO, K
中科院分区：
文献类型：
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作者：
ISHIKURA, H;KANDA, M;MIZUNO, K
对7例甲胎蛋白（AFP）产生的肺癌进行了组织学研究，以确定它们是否属于任何先前描述的类别。患者均为男性，年龄40 ~ 73岁，血清AFP水平为1039 ~ 320，000 ng/ml。本文报告肝样腺癌5例，内胚窦瘤1例，乳头状腺癌1例，并讨论了肿瘤的可能来源及鉴别诊断。 肝样腺癌是产生AFP的肺癌中的主要组织学类型;其他类型较少见。肝样腺癌在胃和肺的发生表明，这种肿瘤也可以在其他器官的内胚层起源。它可能是产生AFP的非生殖细胞来源的内胚层肿瘤的主要组织学亚型。
Seven cases of the alpha-fetoprotein (AFP)-producing lung carcinoma were studied histologically to determine whether they fell into any previously described category. The patients were all males from 40 to 73 years of age and their serum AFP levels ranged from 1039 to 320,000 ng/ml. Five cases of hepatoid adenocarcinoma, one case of endodermal sinus tumour, and one case of papillary adenocarcimoma were found. The possible origins of the tumours and their differential diagnosis are discussed. Hepatoid adenocarcinoma is a major histological category among AFP-producing lung carcinoma; other types are less frequent. The occurrence of hepatoid adenocarcinoma in both the stomach and the lung suggests that this neoplasm may also be seen in other organs of endodermal origin. It may be a major histological subtype of AFP-producing endodermal neoplasms of non-germ cell origin.