MORPHOMETRY OF EXERCISE-INDUCED RIGHT VENTRICULAR HYPERTROPHY IN THE RAT
MORPHOMETRY OF EXERCISE-INDUCED RIGHT VENTRICULAR HYPERTROPHY IN THE RAT
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DOI：
10.1161/01.res.52.1.57
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发表时间：
1983-01-01
影响因子：
20.1
通讯作者：
KIKKAWA, Y
中科院分区：
文献类型：
--
作者：
ANVERSA, P;LEVICKY, V;KIKKAWA, Y
在一项运动对心脏影响的研究中，5周龄的雄性Wistar-Kyoto大鼠每天进行适度的跑步机跑步计划，持续7周。心脏通过右心室（22%）和左心室（7%）心肌组织生长的不同幅度对物理调节作出反应，后者的变化无统计学意义。右心室容积的增加与心室面积增大25%、心肌细胞平均延长26%相关，而肌节长度和心室中壁厚度无变化。运动引起右心室微血管定量参数的显著改变，但左心室无明显变化。右心室肥大的特征是通过毛细血管数密度增加16%和毛细血管网络总长度增加41%而引起的内皮管腔表面的绝对44%生长。从毛细血管壁到肌细胞线粒体的最大扩散距离减少了10%，这是由于毛细血管增生和肌细胞横截面积缺乏侧向扩张。评价的亚细胞成分的肌细胞显示没有变化的线粒体肌原纤维体积比，表明这些组件的增长成正比，彼此和作为一个整体的肌细胞群体的增长。显然，右心室生长类似于离心性肥大，其中毛细血管床的结构适应性可以预期改善组织内O2的扩散和运输。
In a study of the effects of exercise on the heart, male Wistar-Kyoto rats at 5 wk of age were subjected daily to a moderate treadmill running program that lasted for 7 wk. The heart responded to physical conditioning by different magnitudes of tissue growth of the right (22%) and left (7%) ventricular myocardium, the latter change not statistically signfiicant. The increase in right ventricular volume was associated with a 25% enlargement of ventricular area, a 26% average lengthening of the myocytes, and no change in sarcomere length and in ventricular midwall thickness. Exercise produced significant alterations in the quantitative parameters of the microvasculature of the right ventricle, but no appreciable changes in the left ventricle. Right ventricular hypertrophy was characterized by an absolute 44% growth of the endothelial luminal surface brought about through a 16% increase in capillary numerical density and a 41% augmentation of the total length of the capillary network. Maximum diffusion distance from the capillary wall to the mitochondria of myocytes decreased 10% as a result of capillary proliferation and the lack of lateral expansion of myocyte cross-sectional area. Evaluation of the subcellular constituents of myocytes showed no change in the mitochondria myofibrils volume ratio, indicating a growth of these components proportional to each other and to the growth of the myocyte population as a whole. Apparenty, right ventricular growth is analogous to eccentric hypertrophy in which the structural adaptations of the capillary bed can be expected to improve the diffusion and transport of O2 within the tissue.