Comparative neurovirulence and latency of hsv1 and hsv2 following footpad inoculation in mice
Comparative neurovirulence and latency of hsv1 and hsv2 following footpad inoculation in mice
复制标题
小鼠足垫接种后 hsv1 和 hsv2 的神经毒力和潜伏期比较
DOI：
10.1002/jmv.1890050104
复制
发表时间：
1980
影响因子：
12.7
通讯作者：
R. R. Mckendall
中科院分区：
文献类型：
--
作者：
R. R. Mckendall
在Balb/c和ICR小鼠足垫接种中研究了病毒剂量和动物年龄对HSV 1和HSV 2急性和潜伏性神经系统感染外观的影响。在低病毒剂量下，发现HSV 2的神经毒性比HSV 1高1，500倍。在高剂量下，神经毒性没有差异。年龄获得性疾病抵抗力显示HSV 2比HSV 1更不完全。神经毒力被证明与感染扩散到脊神经节有关。数据表明，导致这两种病毒不同神经毒力的因素与足垫和/或坐骨神经水平的事件相关。
The effect of virus dose and animal age on the appearance of acute and latent neurologic infection by HSV1 and HSV2 was studied in Balb/c and ICR mice inoculated in the footpad. At low viral doses HSV2 was found to be 1,500 times more neurovirulent than HSV1. At high doses there was no difference in neurovirulence. Age‐acquired resistance to disease was shown to be less complete with HSV2 than with HSV1. Neurovirulence was shown to be associated with spread of infection to the spinal ganglia. The data indicate that the factor(s) responsible for the differential neurovirulence of these two viruses is related to events at the level of the footpad and/or sciatic nerve.