Coffee consumption, gender, and Parkinson's disease mortality in the Cancer Prevention Study II cohort: The modifying effects of estrogen
Coffee consumption, gender, and Parkinson's disease mortality in the Cancer Prevention Study II cohort: The modifying effects of estrogen
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DOI：
10.1093/aje/kwh312
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发表时间：
2004-11-15
影响因子：
5
通讯作者：
Thun, MJ
中科院分区：
文献类型：
--
作者：
Ascherio, A;Weisskopf, MG;Thun, MJ
咖啡因消费与男性帕金森病风险降低有关，但与女性无关。这种性别差异可能是由于咖啡因和使用绝经后雌激素之间的相互作用。作者前瞻性地评估了癌症预防研究II参与者中咖啡消费与帕金森病死亡率之间的关系，该研究于1982年招募了超过100万人。死亡原因通过1989年1月1日至1998年的死亡证明确定。帕金森病被列为909名男性和340名女性的死亡原因。在调整了年龄、吸烟和饮酒量后，男性咖啡摄入量与帕金森病死亡率呈负相关（p（趋势）= 0.01），但女性则不然（p = 0.6）。在女性中，这种关联依赖于绝经后雌激素的使用;与不喝咖啡的人相比，每天喝4杯或更多杯（600毫升）咖啡的女性的相对风险为0.47（95%置信区间：0.27，0.80; p = 0.006）和1.31（95%置信区间：0.75，2.30; p = 0.34）。这些结果表明，咖啡因可以降低患帕金森病的风险，但这种假设的有益作用可能会被雌激素替代疗法所阻止。
Caffeine consumption is associated with a reduced risk of Parkinson's disease in men but not in women. This gender difference may be due to an interaction between caffeine and use of postmenopausal estrogens. The authors prospectively assessed the relation between coffee consumption and Parkinson's disease mortality among participants in the Cancer Prevention Study II, a cohort of over 1 million people enrolled in 1982. Causes of deaths were ascertained through death certificates from January 1, 1989, through 1998. Parkinson's disease was listed as a cause of death in 909 men and 340 women. After adjustment for age, smoking, and alcohol intake, coffee consumption was inversely associated with Parkinson's disease mortality in men (p(trend) = 0.01) but not in women (p = 0.6). In women, this association was dependent on postmenopausal estrogen use; the relative risk for women drinking 4 or more cups (600 ml) of coffee per day compared with nondrinkers was 0.47 (95% confidence interval: 0.27, 0.80; p = 0.006) among never users and 1.31 (95% confidence interval: 0.75, 2.30; p = 0.34) among users. These results suggest that caffeine reduces the risk of Parkinson's disease but that this hypothetical beneficial effect may be prevented by use of estrogen replacement therapy.