Vitamin D deficiency is common in children and adolescents with chronic kidney disease.
Vitamin D deficiency is common in children and adolescents with chronic kidney disease.
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DOI：
10.1038/ki.2011.431
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发表时间：
2012-04
影响因子：
19.6
通讯作者：
中科院分区：
文献类型：
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作者：
Here we determined if vitamin D deficiency is more common in children with chronic kidney disease compared to healthy children. In addition we sought to identify disease-specific risk factors for this deficiency as well as its metabolic consequences. We found that nearly half of 182 patients (ages 5 to 21) with kidney disease (stages 2 to 5) and a third of age-matched 276 healthy children were 25-hydroxyvitamin D deficient (less than 20 ng/ml). The risk of deficiency was significantly greater in advanced disease. Focal segmental glomerulosclerosis and low albumin were significantly associated with lower 25-hydroxyvitamin D which, in turn, was associated with significantly higher intact parathyroid hormone levels. We found that 25-hydroxyvitamin D levels were positively associated with 1,25-dihydroxyvitamin D, the relationship being greatest in advanced disease (significant interaction), and inversely related to those of inflammatory markers C-reactive protein and IL-6. The association with C-reactive protein persisted when adjusted for the severity of kidney disease. Thus, lower 25-hydroxyvitamin D may contribute to hyperparathyroidism, inflammation and lower 1,25-dihydroxyvitamin D in children and adolescents, especially those with advanced kidney disease.
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影响因子：
2.5
作者：
Elder, Grahame J.
通讯作者：
Elder, Grahame J.
影响因子：
--
作者：
Jean, G.;Lataillade, D.;Fouque, D.
通讯作者：
Fouque, D.
影响因子：
3
作者：
Menon, Shina;Valentini, Rudolph P.;Mattoo, Tej K.
通讯作者：
Mattoo, Tej K.
影响因子：
19.6
作者：
Chonchol, M.;Scragg, R.
通讯作者：
Scragg, R.
影响因子：
10.6
作者：
Holick, Michael F.
通讯作者：
Holick, Michael F.