Herbal medicine today: clinical and research issues.
Herbal medicine today: clinical and research issues.
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今天的草药：临床和研究问题。
DOI：
10.1093/ecam/nem096
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发表时间：
2007-09
影响因子：
--
通讯作者：
Gori, Luigi
中科院分区：
文献类型：
--
作者：
Firenzuoli, Fabio;Gori, Luigi
关键词：
草药是利用药用植物来预防和治疗疾病：它的范围从每个国家的传统和受欢迎的药物到使用标准化的和经过磨练的草药提取物。一般来说，在传统医疗系统中持久和广泛使用的文化根基可能表明治疗的安全性，但并不意味着治疗的有效性，特别是在草药方面，传统几乎完全基于含有极低和极低浓度的有效成分的补救措施，或依赖于神奇的能量原则。在全球化和所谓的“平板世界”的时代，评估治疗在不同文化之间的“可转换性”并不是临床研究的相关目标，而疗效和安全性的评估应该基于主流临床医学的规则模式。草药治疗的另一个黑箱是缺乏关于提取物成分的明确和完整的信息。草药衍生药物需要对其药理质量和安全性进行强有力和深入的评估，而这些评估实际上可以通过药物基因组学、代谢组学和微阵列方法学等新的生物技术来实现。由于天然衍生物质在世界各地的大量和日益增长的使用，还依赖于传统或所谓的千禧年信仰是不明智的；解释性和实用性研究是有用的，应该被认为是为卫生保健人员和患者获取可靠数据的补充。
Herbal medicine is the use of medicinal plants for prevention and treatment of diseases: it ranges from traditional and popular medicines of every country to the use of standardized and tritated herbal extracts. Generally cultural rootedness enduring and widespread use in a Traditional Medical System may indicate safety, but not efficacy of treatments, especially in herbal medicine where tradition is almost completely based on remedies containing active principles at very low and ultra low concentrations, or relying on magical-energetic principles. In the age of globalization and of the so-called ‘plate world’, assessing the ‘transferability’ of treatments between different cultures is not a relevant goal for clinical research, while are the assessment of efficacy and safety that should be based on the regular patterns of mainstream clinical medicine. The other black box of herbal-based treatments is the lack of definite and complete information about the composition of extracts. Herbal derived remedies need a powerful and deep assessment of their pharmacological qualities and safety that actually can be realized by new biologic technologies like pharmacogenomic, metabolomic and microarray methology. Because of the large and growing use of natural derived substances in all over the world, it is not wise to rely also on the tradition or supposed millenarian beliefs; explanatory and pragmatic studies are useful and should be considered complementary in the acquisition of reliable data both for health caregiver and patients.
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影响因子：
3.6
作者：
Cardini, Francesco;Wade, Christine;Kronenberg, Fredi
通讯作者：
Kronenberg, Fredi
影响因子：
17.7
作者：
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通讯作者：
Wells, KB
影响因子：
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作者：
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通讯作者：
Cajulis, OS
影响因子：
39.2
作者：
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通讯作者：
Bombardier, C
影响因子：
--
作者：
Nahin, RL;Straus, SE
通讯作者：
Straus, SE