Cerebral ischemia in the presence of lupus anticoagulant.
Cerebral ischemia in the presence of lupus anticoagulant.
复制标题
狼疮抗凝物存在时发生脑缺血。
DOI：
10.1001/archneur.1984.04050170067020
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发表时间：
1984
影响因子：
--
通讯作者：
A. Kovacs
中科院分区：
文献类型：
--
作者：
R. Kelley;P. Gilman;A. Kovacs
两例有脑缺血表现的患者被发现有循环凝血抑制剂。这种免疫球蛋白，称为狼疮抗凝剂，导致部分凝血活酶时间延长。矛盾的是，它通常与血栓形成倾向而不是出血性素质有关。这是最常见于系统性红斑狼疮，我们的病人没有。这两名患者代表了内源性凝血抑制剂存在下脑缺血的有趣现象。
Two patients with manifestations of cerebral ischemia were found to have a circulating coagulation inhibitor. This immunoglobulin, termed lupus anticoagulant, results in a prolonged partial thromboplastin time. Paradoxically, it is usually associated with a thrombotic tendency rather than a bleeding diathesis. It is most commonly found in systemic lupus erythematosus, which our patients did not have. These two patients represent the interesting phenomenon of cerebral ischemia in the presence of an endogenous inhibitor of coagulation.