Effect of chronic and acute cigarette smoking on the pharyngoglottal closure reflex
Effect of chronic and acute cigarette smoking on the pharyngoglottal closure reflex
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DOI：
10.1136/gut.51.6.771
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发表时间：
2002-12-01
期刊：
影响因子：
24.5
通讯作者：
Shaker, R
中科院分区：
文献类型：
--
作者：
Dua, K;Bardan, E;Shaker, R
背景：向咽部注入一定量的水可引起声带内收-咽声门闭合反射（PGCR）。这种反射与其他食管上反射一起可能有助于防止误吸。吸烟对咽-食管上括约肌收缩反射和反射性咽吞咽有不良影响。吸烟对PGCR的影响以前没有研究过。目的：阐明慢性和急性吸烟对PGCR的影响。对象：我们研究了10名慢性吸烟者和10名非吸烟者在真实的/模拟吸烟前后的PGCR。方法：使用同步记录，通过视频内窥镜监测声门功能，通过肌电图监测吞咽，结果：慢性吸烟者咽部快速注水触发PGCR的阈值明显高于非吸烟者（0.20（SEM0.02）ml），吸烟者（0.36（0.02）ml）;
Background: Injection of water into the pharynx at a threshold volume induces vocal cord adduction-the pharyngoglottal closure reflex (PGCR). This reflex together with other supraoesophageal reflexes may be helpful in preventing aspiration. Cigarette smoking has an adverse affect on the pharyngo-upper oesophageal sphincter contractile reflex and reflexive pharyngeal swallow. The effect of smoking on PGCR has not been studied previously.Aims: To elucidate the effect of chronic and acute cigarette smoking on PGCR.Subjects: We studied 10 chronic smokers and 10 non-smokers before and after real/simulated smoking, respectively.Methods: Using concurrent recordings, glottal function was monitored by video endoscopy, swallowing by electromyography, and PGCR was triggered by rapid and slow pharyngeal water injections.Results: The threshold volume to trigger PGCR during rapid injection was significantly higher in chronic smokers (non-smoker 0.20 (SEM 0.02) ml, smoker 0.36 (0.02) ml; p