Supraoptic nucleus of the Brattleboro rat has an altered afferent noradrenergic input.

Supraoptic nucleus of the Brattleboro rat has an altered afferent noradrenergic input.
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布拉特尔伯勒大鼠的视上核具有改变的传入去甲肾上腺素能输入。

DOI:
10.1126/science.7053181
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发表时间:
1981
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
SladekJr,JR
SladekJr,JR
中科院分区:
--
文献类型:
--
作者:
Schöler,J;SladekJr,JR

文献摘要

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The distribution of fluorescent varicosities in the supraoptic nucleus of Brattleboro rats was compared to that in normal rats. The Brattleboro rat, which is characterized by a genetic absence of vasopressin, had fewer fluorescent varicosities in apposition to the vasopressin-deficient perikarya. The oxytocin-producing neurons in the same nucleus were hyperinnervated. These data suggest that the target neuron peptide (vasopressin) is necessary for the maintenance of normal noradrenergic innervation patterns.