Phantom Limbs, Neuroprosthetics, and the Developmental Origins of Embodiment.
Phantom Limbs, Neuroprosthetics, and the Developmental Origins of Embodiment.
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DOI：
10.1016/j.tins.2017.07.003
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发表时间：
2017-10
影响因子：
15.9
通讯作者：
Dooley JC
中科院分区：
文献类型：
--
作者：
Blumberg MS;Dooley JC
截肢者如果想摆脱幻肢，就必须削弱对缺失肢体的神经表征。相反，希望替换失去肢体的截肢者必须将神经假体与现有的神经表示同化。无论我们是希望移除幻肢还是同化合成的幻肢，我们都将受益于更多地了解实现化身的发育过程。一个潜在的关键因素是自发活动-以肢体抽搐的形式-只发生在活跃（REM）睡眠期间，这是早期发育中特别突出的状态。由抽搐的肢体激活的感觉运动回路，以及激活发生的发育背景，可以为创造感觉好像是身体一部分的神经假肢提供路线图。
Amputees who wish to rid themselves of a phantom limb must weaken the neural representation of the absent limb. Conversely, amputees who wish to replace a lost limb must assimilate a neuroprosthetic with the existing neural representation. Whether we wish to remove a phantom limb or assimilate a synthetic one, we will benefit from knowing more about the developmental process that enables embodiment. A potentially critical contributor to that process is the spontaneous activity—in the form of limb twitches—that occurs exclusively and abundantly during active (REM) sleep, a particularly prominent state in early development. The sensorimotor circuits activated by twitching limbs, and the developmental context in which activation occurs, could provide a roadmap for creating neuroprosthetics that feel as if they are part of the body.
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影响因子：
25
作者：
Dadarlat, Maria C.;O'Doherty, Joseph E.;Sabes, Philip N.
通讯作者：
Sabes, Philip N.
影响因子：
19.9
作者：
Byrge, Lisa;Sporns, Olaf;Smith, Linda B.
通讯作者：
Smith, Linda B.
影响因子：
9.2
作者：
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通讯作者：
McMurray, Bob
影响因子：
2.5
作者：
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通讯作者：
Cole, J
影响因子：
10.5
作者：
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通讯作者：
Plumeau AM