Three-Component Synthesis of Neoglycopeptides Using a Cu(II)-Triggered Aminolysis of Peptide Hydrazide Resin and an Azide-Alkyne Cycloaddition Sequence
Three-Component Synthesis of Neoglycopeptides Using a Cu(II)-Triggered Aminolysis of Peptide Hydrazide Resin and an Azide-Alkyne Cycloaddition Sequence
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DOI：
10.1021/ol201659x
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发表时间：
2011-08-19
期刊：
影响因子：
5.2
通讯作者：
Melnyk, Oleg
中科院分区：
文献类型：
--
作者：
Ebran, Jean-Philippe;Dendane, Nabil;Melnyk, Oleg
铜（II）诱导的酰肼氧化氨解生成Cu（I），其为叠氮化物-炔环加成的催化剂。利用这一特点设计了一种新的固相分离三组分反应，允许支持的肽酰肼转化为1，2，3-三唑连接的C-末端neoglycopeptides。
Copper(II)-induced oxidative aminolysis of hydrazides generates Cu(I), the catalyst of the azide-alkyne cycloaddition. This feature was exploited to design a novel solid phase detaching three-component reaction permitting the conversion of supported peptide hydrazides into 1,2,3-triazole linked C-terminal neoglycopeptides.