Lateral hypothalamic circuits for feeding and reward.
Lateral hypothalamic circuits for feeding and reward.
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DOI：
10.1038/nn.4220
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发表时间：
2016-02
影响因子：
25
通讯作者：
Wise RA
中科院分区：
文献类型：
--
作者：
Stuber GD;Wise RA
在60多年前进行的实验中，下丘脑外侧区（LHA）被确定为动机行为的关键神经解剖学基底。对LHA的电刺激即使在非限制性动物中也会引起贪婪的进食。在没有食物的情况下，动物会不知疲倦地工作，通常每小时按压1000次，在同一部位进行电刺激，激发进食，饮水和其他物种典型的动机行为。在这里，我们回顾了电刺激研究的经典发现，并将其与最近的工作，利用当代电路为基础的方法来研究LHA。我们确定了特定的解剖学和分子定义的LHA元素，整合了来自皮质，扩展杏仁核和基底前脑网络的各种信息，最终产生一个高度指定和简化的行为状态，通过LHA预测传达到下游的奖励和喂养特定的电路。
In experiments conducted over 60 years ago, the lateral hypothalamic area (LHA) was identified as a critical neuroanatomical substrate for motivated behavior. Electrical stimulation of the LHA induces voracious feeding even in non-restricted animals. In the absence of food, animals will work tirelessly, often lever-pressing 1000’s of times per hour, for electrical stimulation at the same site that provokes feeding, drinking, and other species-typical motivated behaviors. Here we review the classic findings from electrical stimulation studies and integrate them with more recent work that has utilized contemporary circuit-based approaches to study the LHA. We identify specific anatomically and molecularly defined LHA elements that integrate diverse information arising from cortical, extended amygdala, and basal forebrain networks to ultimately generate a highly specified and invigorated behavioral state conveyed via LHA projections to downstream reward and feeding specific circuits.