Tuning Magnetic Property and Autophagic Response for Self-Assembled Ni-Co Alloy Nanocrystals
Tuning Magnetic Property and Autophagic Response for Self-Assembled Ni-Co Alloy Nanocrystals
复制标题
调节自组装镍钴合金纳米晶体的磁性能和自噬反应。
DOI：
10.1002/adfm.201203767
复制
发表时间：
2013-12-17
影响因子：
19
通讯作者：
Wen, Long-Ping
中科院分区：
文献类型：
--
作者：
Dong, Liang;Liu, Yun;Wen, Long-Ping
诱导自噬是细胞暴露于纳米材料后的常见反应，代表了工程纳米材料的安全性问题和应用利基。在此，据报道，磁性和自噬诱导活性的Ni-Co合金纳米晶（NC）组件可以通过改变材料组成差异调谐。在微波辐射下，在水溶液中快速合成了一系列由粒径约为30 nm的纳米颗粒组成的Ni-Co合金NC组装体。由于纳米粒子的强磁矩和外加磁场的作用，观察到了可控的自组装效应。有趣的是，饱和磁化强度（Ms）随组分摩尔比的变化呈现“过山车”效应，而自噬诱导活性和毒性随镍组分的增加呈现升高趋势。自噬反应部分促成了观察到的NC组装体的细胞毒性，因为自噬的抑制部分但显著地降低了毒性。因此，通过调整合金的组成，可以设计和开发满足不同应用需求的最佳Ni-Co NC，例如诊断成像（最大磁化和低自噬反应）或磁导向癌细胞杀伤（最大自噬反应和足够的磁化）。
Induction of autophagy is a common response of cells upon exposure to nanomaterials and represents both a safety concern and an application niche for engineered nanomaterials. Herein, it is reported that the magnetic property and the autophagy-inducing activity for Ni-Co alloy nanocrystal (NC) assemblies can be differentially tuned through altering the material composition. A series of Ni-Co alloy NC assemblies, composed of nanoparticles (NPs) with a size of about 30 nm, can be quickly synthesized under microwave irradiation in aqueous solution. A controllable self-assembling effect is observed due to the strong magnetic moment of NPs and external magnetic field. Interestingly, the saturation magnetization (Ms) shows a roller coaster' effect with varying component molar ratio, while the autophagy-inducing activity and toxicity of these alloy NCs presents an elevated tendency with the increase of nickel component. The autophagic response partly contributes to the observed cellular toxicity of the NC assemblies, as inhibition of autophagy partially but significantly reduces toxicity. Therefore, through tuning the composition of the alloy, optimal Ni-Co NCs satisfying the needs of different applications such as diagnostic imaging (maximum magnetization and low autophagic response) or magnetically-directed cancer cell killing (maximum autophagic response and sufficient magnetization) may be designed and developed.