SENSITIVITY OF THE EYES TO AIRBORNE IRRITANT STIMULI - INFLUENCE OF INDIVIDUAL CHARACTERISTICS
SENSITIVITY OF THE EYES TO AIRBORNE IRRITANT STIMULI - INFLUENCE OF INDIVIDUAL CHARACTERISTICS
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DOI：
10.1080/00039896.1992.9935943
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发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
MOLHAVE, L
中科院分区：
文献类型：
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作者：
KJAERGAARD, S;PEDERSEN, OF;MOLHAVE, L
本研究的目的是测量眼睛对刺激性暴露的三叉神经敏感性，并检查个体特征（如性别、年龄和吸烟）对这种敏感性的影响。在一项实验研究中，研究人员对2025名随机选择的志愿者中的158人进行了眼睛对二氧化碳的感觉刺激阈值检测。眼睛暴露在二氧化碳浓度（10,20,40,80,160 ml/l）中，直到受试者声称有明显的刺激。每个暴露水平持续2分钟。一种特殊的暴露面罩系统用于仅眼睛暴露。没有发现性别或吸烟的显著依赖性，但年龄小于40岁的受试者比老年受试者更敏感。经常报告“病态建筑综合征”刺激症状的受试者阈值较低（即敏感性较高）。二氧化碳阈值与皮肤刺激敏感性有关，即对脸颊涂抹乳酸的反应，有迹象表明职业压力与低阈值有关。对正癸烷刺激的研究表明，CO2阈值可能是预测个体对空气污染物刺激敏感性的重要因素。眼睛的CO2阈值可能对室内空气污染超敏反应的评价有价值。此外，阈值可用于评估不同三叉神经支配区域（如皮肤和眼睛）之间的重要关系。最后，该方法具有避免嗅觉刺激干扰的优点。
The purpose of this study was to measure trigeminal sensitivity of the eyes to irritative exposures and to examine the influence of individual characteristics, e.g., gender, age, and smoking, on this sensitivity. During an experimental study, 158 of 2 025 randomly selected volunteers were examined for sensory irritation threshold in the eyes to carbon dioxide (CO2). Eyes were exposed to progressive concentrations of CO2 (10, 20, 40, 80, and 160 ml/l), until the subject claimed a distinct irritation. Each exposure level lasted 2 min. A special exposure mask system was used for eyes-only exposure. No significant dependence of gender or smoking was found, but subjects who were less than 40 y of age were more sensitive than were the elderly subjects. Subjects who reported frequent "sick building syndrome" irritation symptoms had lower thresholds (i.e., higher sensitivity). The CO2 threshold was related to skin irritation sensitivity, i.e., response to lactic acid smeared on the cheek, and there were indications that occupational stress was associated with low thresholds. Studies of irritation to n-decane indicate that the CO2 threshold may be an important factor in the prediction of individual sensitivity to irritation from airborne pollutants. The CO2 threshold of the eyes may be of value in the evaluation of hypersensitivity to indoor air pollution. Furthermore, the threshold may be used to assess important relationships between the different trigeminal innervated areas, e.g., skin and eyes. Finally, the method has the advantage of avoiding interference from olfactory stimulation.