Malectin/Malectin-like domain-containing proteins: A repertoire of cell surface molecules with broad functional potential.
Malectin/Malectin-like domain-containing proteins: A repertoire of cell surface molecules with broad functional potential.
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DOI：
10.1016/j.tcsw.2021.100056
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Cheung AY
中科院分区：
文献类型：
--
作者：
Yang H;Wang D;Guo L;Pan H;Yvon R;Garman S;Wu HM;Cheung AY
细胞壁位于有壁生物与其环境之间相互作用的最前线。它们支持细胞扩张，确保细胞完整性，并且对于植物等多细胞生物，它们提供细胞粘附，支持细胞形状形态发生并介导细胞间通讯。细胞壁感应、检测细胞壁的扰动并向细胞发出相应的信号做出反应，对于生长和生存至关重要。近年来，植物信号传导研究表明，一大类受体样激酶（RLK）可以充当壁传感器，部分原因是它们的细胞外结构域与 malectin（一种来自动物细胞内质网的二葡萄糖结合蛋白）具有同源性。对来自模式植物拟南芥的几种含有 malectin/mallectin 样 (M/ML) 结构域的 RLK (M/MLD-RLK) 的研究揭示了一系列令人印象深刻的生物学作用，控制生长、繁殖和应激反应，这些过程以各种方式依赖或影响细胞壁。 Mallectin 同源序列在生物界中广泛存在，但植物独特地进化出了一个高度扩展的蛋白质家族，其 ML 结构域嵌入到各种蛋白质环境中。在这里，我们对不同界中具有 malectin 同源序列的蛋白质进行了概述，讨论了拟南芥 M/MLD-RLK 的染色体组织以及来自几种模式和作物物种的这些蛋白质之间的系统发育关系。我们还简要讨论了迄今为止研究的 M/MLD-RLK 发挥多种生物学作用的分子网络。
Cell walls are at the front line of interactions between walled-organisms and their environment. They support cell expansion, ensure cell integrity and, for multicellular organisms such as plants, they provide cell adherence, support cell shape morphogenesis and mediate cell–cell communication. Wall-sensing, detecting perturbations in the wall and signaling the cell to respond accordingly, is crucial for growth and survival. In recent years, plant signaling research has suggested that a large family of receptor-like kinases (RLKs) could function as wall sensors partly because their extracellular domains show homology with malectin, a diglucose binding protein from the endoplasmic reticulum of animal cells. Studies of several malectin/malectin-like (M/ML) domain-containing RLKs (M/MLD-RLKs) from the model plant Arabidopsis thaliana have revealed an impressive array of biological roles, controlling growth, reproduction and stress responses, processes that in various ways rely on or affect the cell wall. Malectin homologous sequences are widespread across biological kingdoms, but plants have uniquely evolved a highly expanded family of proteins with ML domains embedded within various protein contexts. Here, we present an overview on proteins with malectin homologous sequences in different kingdoms, discuss the chromosomal organization of Arabidopsis M/MLD-RLKs and the phylogenetic relationship between these proteins from several model and crop species. We also discuss briefly the molecular networks that enable the diverse biological roles served by M/MLD-RLKs studied thus far.