Pheochromocytoma of the adrenal gland scaled score (PASS) to separate benign from malignant neoplasms - A clinicopathologic and immunophenotypic study of 100 cases
Pheochromocytoma of the adrenal gland scaled score (PASS) to separate benign from malignant neoplasms - A clinicopathologic and immunophenotypic study of 100 cases
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DOI：
10.1097/00000478-200205000-00002
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发表时间：
2002-05-01
影响因子：
5.6
通讯作者：
Thompson, LDR
中科院分区：
文献类型：
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作者：
Thompson, LDR
目前还没有全面的系列评价嗜铬细胞瘤的组织学特征，仅通过组织形态学参数来区分嗜铬细胞瘤的良恶性。从武装部队病理研究所的档案中检索了50例组织学上恶性和50例组织学上良性的肾上腺嗜铬细胞瘤。其中女性43例，男性57例，年龄3 ~ 81岁，平均46.7岁。患者通常有高血压（n = 79例）。平均肿瘤大小为7.2 cm（体重222 g）。组织学上，肾上腺恶性嗜铬细胞瘤多表现为浸润（血管[1分]，包膜[1分]，肾上腺周围脂肪组织[2分]），大巢状或弥漫性生长（2分），局灶性或融合性坏死（2分），高细胞性（2分），肿瘤细胞纺锤状（2分），细胞单调（2分），有丝分裂象增高(>3/10高倍视野；评分= 2)，非典型有丝分裂象（评分= 2），深度核多形性（评分= 1），色素沉着（评分= 1）明显高于良性肿瘤。肾上腺嗜铬细胞瘤的分级评分（PASS）对这些特定的组织学特征进行加权，可用于区分具有潜在生物攻击性行为（PASS大于或等于4）的肿瘤与表现为良性的肿瘤（PASS）
No comprehensive series has evaluated the histologic features of pheochromocytoma to separate benign from malignant pheochromocytoma by histomorphologic parameters only. Fifty histologically malignant and 50 histologically benign pheochromocytomas of the adrenal gland were retrieved from the files of the Armed Forces Institute of Pathology. The patients included 43 females and 57 males, with an age range of 3-81 years (mean 46.7 years). Patients usually experienced hypertension (n = 79 patients). The mean tumor size was 7.2 cm (weight was 222 g). Histologically, the cases of malignant pheochromocytomas of the adrenal gland more frequently demonstrated invasion (vascular [score 1], capsular [score = 1], periadrenal adipose tissue [score = 2]), large nests or diffuse growth (score = 2), focal or confluent necrosis (score = 2), high cellularity (score = 2), tumor cell spindling (score = 2), cellular monotony (score = 2), increased mitotic figures (>3/10 high power fields; score = 2), atypical mitotic figures (score = 2), profound nuclear pleomorphism (score = 1), and hyperchromasia (score = 1) than the benign tumors. A Pheochromocytoma of the Adrenal gland Scaled Score (PASS) weighted for these specific histologic features can be used to separate turnors with a potential for a biologically aggressive behavior (PASS greater than or equal to4) from tumors that behave in a benign fashion (PASS