Cerebral abnormalities: use of calculated T1 and T2 magnetic resonance images for diagnosis.
Cerebral abnormalities: use of calculated T1 and T2 magnetic resonance images for diagnosis.
复制标题
脑异常：使用计算的 T1 和 T2 磁共振图像进行诊断。
DOI：
10.1148/radiology.150.1.6689792
复制
发表时间：
1984
期刊：
影响因子：
19.7
通讯作者：
Brant-Zawadzki,M
中科院分区：
文献类型：
--
作者：
Mills,CM;Crooks,LE;Kaufman,L;Brant-Zawadzki,M
T1和T2弛豫时间在区分正常和病理组织与磁共振（MR）的潜在临床意义进行了讨论，并给出了脑异常的临床例子。T1和T2值可以以三种方式使用：（a）如果诊断不需要T1和T2的绝对值，则可以使用通过分析具有对T1和T2的变化依赖性的强度图像获得的相对值。(b)如果需要绝对值，则可以使用强度图像上的感兴趣区域来生成驰豫时间的数值。(c)在T1和T2均发生变化的情况下，可能需要计算图像来指示每个变化对信号强度的贡献，数值可用于生成T1或T2计算的模拟图像。对5名脑梗塞患者、15名多发性硬化症患者、2名威尔逊病患者和4名肿瘤患者进行了成像。使用自旋回波技术区分出血性和缺血性脑血管意外。多发性硬化患者病变T1、T2时间延长，但斑块的定义受空间分辨率的限制。在不再严重残疾的威尔逊病患者中未观察到信号强度异常;在第二例威尔逊病患者中发现基底节信号强度异常增加。四个肿瘤产生异常的T1和T2弛豫时间，但这些值本身是不够的肿瘤表征。
The potential clinical importance of T1 and T2 relaxation times in distinguishing normal and pathologic tissue with magnetic resonance (MR) is discussed and clinical examples of cerebral abnormalities are given. T1 and T2 values may be used in three ways: (a) Relative values, obtained by an analysis of intensity images with varying dependence on T1 and T2, may be used if absolute values for T1 and T2 are not required for diagnosis. (b) If an absolute value is desired, the numerical values for the relaxation times may be generated using a region of interest on the intensity images. (c) In cases in which both T1 and T2 change may require a calculated image to indicate the contribution of each to the signal intensity, the numerical value may be used to generate analogue images of T1 or T2 calculations. Five patients with cerebral infarction, 15 with multiple sclerosis, two with Wilson disease, and four with tumors were imaged. Hemorrhagic and ischemic cerebrovascular accidents were distinguished using the spin echo technique. In the patients with multiple sclerosis, lesions had prolonged T1 and T2 times, but the definition of plaque was limited by spatial resolution. No abnormalities in signal intensity were seen in the patient with Wilson disease who was no longer severely disabled; abnormal increased signal intensity in the basal ganglia was found in the second patient with Wilson disease. Four tumors produced abnormal T1 and T2 relaxation times but these values alone were not sufficient for tumor characterization.