Prenatal ethanol exposure in mice: teratogenic effects.
Prenatal ethanol exposure in mice: teratogenic effects.
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小鼠产前乙醇暴露：致畸作用。
DOI：
10.1002/tera.1420190305
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
W. Taylor
中科院分区：
文献类型：
--
作者：
C. Randall;W. Taylor
C57 BL/6 J小鼠从妊娠第5天至第10天喂食流质饮食，其中17%、25%或30%的卡路里来自乙醇。对照组小鼠喂食实验室食物或配对喂食相同的饮食，不同之处在于蔗糖等热量地取代乙醇。足月时取出胎仔，固定后进行显微解剖检查。胎仔吸收和先天性畸形的发生率以剂量相关方式增加。异常包括骨骼、神经、泌尿生殖和心血管系统。这些数据表明，在小鼠中，含有足够维生素和蛋白质的酒精饮食会导致胎儿浪费和出生缺陷增加。
C57BL/6J mice were fed a liquid diet in which 17, 25, or 30% of the calories were derived from ethanol from the fifth through the tenth day of gestation. Control mice were fed lab chow or pair-fed identical diets, except that sucrose substituted isocalorically for ethanol. At term the fetuses were removed and, following fixation, examined by microdissection. The incidence of fetal resorptions and congenital malformations increased in a dose-related manner. Anomalies included skeletal, neurological, urogenital, and cardiovascular systems. These data indicate that in mice, an alcohol diet which is adequate in vitamins and protein results in increased fetal wastage and birth defects.