Preventing the common cold with a vitamin C supplement: A double-blind, placebo-controlled survey
Preventing the common cold with a vitamin C supplement: A double-blind, placebo-controlled survey
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通过补充维生素 C 预防普通感冒：一项双盲、安慰剂对照调查
DOI：
10.1007/bf02850271
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发表时间：
2002
影响因子：
3.8
通讯作者：
P. Josling
中科院分区：
文献类型：
--
作者：
M. Straten;P. Josling
168名志愿者被随机分为两组，一组服用安慰剂，另一组服用维生素C补充剂，每天两片，在11月至2月的60天内服用。他们使用五点量表来评估他们的健康状况，并在每日日记中记录任何常见的感冒感染和症状。与安慰剂组相比，积极治疗组的感冒次数明显减少（37 vs 50，P<0.05），病毒感染天数减少（85 vs 178），严重症状持续时间明显缩短（1.8 vs 3.1天，P<0.03）。因此，活动组的志愿者不太可能感冒，如果感染，恢复得更快。积极治疗几乎没有副作用，志愿者报告说，与以前任何形式的维生素C相比，研究补充剂的满意度大大提高。这种耐受性良好的维生素C补充剂可以预防普通感冒并缩短症状的持续时间。志愿者普遍对冬季期间提供的保护和研究药物的普遍可接受性印象深刻。
One hundred sixty-eight volunteers were randomized to receive a placebo or a vitamin C supplement, two tablets daily, over a 60-day period between November and February. They used a five-point scale to assess their health and recorded any common cold infections and symptoms in a daily diary. Compared with the placebo group, the active-treatment group had significantly fewer colds (37 vs 50, P<.05), fewer days challenged virally (85 vs 178), and a significantly shorter duration of severe symptoms (1.8 vs 3.1 days, P<.03). Consequently, volunteers in the active group were less likely to get a cold and recovered faster if infected. Few side effects occurred with the active treatment, and volunteers reported greatly increased satisfaction with the study supplement compared with any previous form of vitamin C. This well-tolerated vitamin C supplement may prevent the common cold and shorten the duration of symptoms. Volunteers were generally impressed by the protection afforded them during the winter months and the general acceptability of the study medication.