Stem cells derived from amniotic fluid: new potentials in regenerative medicine
Stem cells derived from amniotic fluid: new potentials in regenerative medicine
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DOI：
10.1016/s1472-6483(10)60111-3
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发表时间：
2009-03-01
影响因子：
4
通讯作者：
De Coppi, Paolo
中科院分区：
文献类型：
--
作者：
Cananzi, Mara;Atala, Anthony;De Coppi, Paolo
人羊水细胞作为产前诊断胎儿遗传异常的诊断工具已有50多年的历史。然而，近5年来的证据表明，它们还具有治疗人类疾病的潜力，因为已经从羊水中分离出不同的胎儿来源干细胞群。间充质干细胞是最早被描述的，它具有成体间充质干细胞的更高的增殖和分化可塑性，并且能够向中胚层谱系分化。羊水干细胞最近被分离出来。它们代表了一类新的多能干细胞，具有介于胚胎干细胞和成体干细胞之间的中间特征。因为它们能够分化成代表所有三个胚层的谱系，但在体内注射时不形成肿瘤。这些特点，加上没有涉及他们的就业道德问题。提示羊水中存在的干细胞可能是组织工程和干细胞治疗几种人类疾病的有希望的候选者。
Human amniotic fluid cells have been used as a diagnostic tool for the prenatal diagnosis of fetal genetic anomalies for more than 50 years. Evidence provided in the fast 5 years, however, suggests that. they can also harbour a therapeutic potential for human diseases, as different populations of fetal-derived stem cells have been isolated from amniotic fluid. Mesenchymal stern cells were the first to be described, which possess the higher proliferation and differentiation plasticity of adult mesenchymal stem cells and are able to differentiate towards mesodermal lineages. Amniotic fluid stern cells have more recently been isolated. They represent a novel class of pluripotent stem cells with intermediate characteristics between embryonic and adult stem cells. as they are able to differentiate into lineages representative of all three germ layers but do not form tumours when injected in vivo. These characteristics, together with the absence of ethical issues concerning their employment. suggest that stem cells present in the amniotic fluid might be promising candidates for tissue engineering and stem cell therapy of several human disorders.