Feasibility of Hair Collection for Cortisol Measurement in Population Research on Adolescent Health.
Feasibility of Hair Collection for Cortisol Measurement in Population Research on Adolescent Health.
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DOI：
10.1097/nnr.0000000000000154
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发表时间：
2016-05
期刊：
影响因子：
2.5
通讯作者：
McCarthy DO
中科院分区：
文献类型：
--
作者：
Ford JL;Boch SJ;McCarthy DO
青少年健康方面的黑人和白人差异很普遍，人们认为部分原因是长期承受压力。从头发中测定皮质醇越来越被认为是慢性生理应激的有效且可靠的测量方法，但在不同青少年的大概率样本中收集头发的可行性尚不清楚。旨在调查种族和社会经济多样化青少年的概率样本中参与皮质醇分析的毛发收集的参与情况，包括社会人口因素和不良暴露与参与的相关程度。该研究包括 516 名青少年的概率样本，以及一项青少年健康前瞻性队列研究。通过家庭访谈、生态瞬时评估（EMA）、全球定位系统（GPS）方法以及周末的家庭毛发收集，在一周内收集数据。在 516 名符合资格的青少年中，有 471 名（91.3%）参与了毛发收集。 45名未提供头发样本的青少年中，有18人头发不足，25人拒绝，还有两人因不明原因没有参加。多变量逻辑回归结果表明，由于头发不足或拒绝，非西班牙裔黑人/非裔美国青年比非西班牙裔白人同龄人参与的可能性更低（OR = 0.24，95% CI [0 .09，0.60]）。尽管参与率较低，但参与样本中黑人/非裔美国青年的比例具有代表性。其他社会人口特征或不良暴露情况未发现参与率存在显着差异。在种族和社会经济多样化的青少年的概率样本中，收集头发用于皮质醇测量是可行的。头发皮质醇分析可能会加速研究进展，以了解健康差异的生物学和心理社会基础。
Black-White disparities in adolescent health are widespread and thought to be explained, in part, by exposure to chronic stress. Cortisol assayed from hair is increasingly recognized as a valid and reliable measure for chronic physiologic stress, but the feasibility of collecting hair among large probability samples of diverse adolescents is unknown. To investigate participation in hair collection for cortisol analyses in a probability sample of racially and socioeconomically diverse adolescents, including the extent to which sociodemographic factors and adverse exposures were associated with participation. The study included a probability sample of 516 adolescents conducted in conjunction with a prospective cohort study on adolescent health. Data were collected over one week via in-home interviews, ecological momentary assessment (EMA), global positioning system (GPS) methods, and in-home hair collection at the end of the week. Of the 516 eligible youth, 471 (91.3%) participated in the hair collection. Of the 45 youth who did not provide hair samples, 18 had insufficient hair, 25 refused, and two did not participate for unknown reasons. Multivariable logistic regression results indicated non-Hispanic Black/African-American youth were less likely than their non-Hispanic White peers to participate due to insufficient hair or refusal (OR = 0.24, 95% CI [0 .09, 0.60]). Despite lower rates of participation, the proportion of Black/African-American youth in the participating sample was representative of the study area. No significant differences in participation were found by other sociodemographic characteristics or adverse exposures. Hair collection for cortisol measurement is feasible among a probability sample of racially and socioeconomically diverse adolescents. Hair cortisol analyses may accelerate research progress to understand the biological and psychosocial bases of health disparities.