Effects of long-term estrogen replacement therapy. II. Neoplasia.
Effects of long-term estrogen replacement therapy. II. Neoplasia.
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长期雌激素替代疗法的影响。
DOI：
10.1097/00006254-197908000-00016
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发表时间：
1979
影响因子：
9.8
通讯作者：
R. T. Parker
中科院分区：
文献类型：
--
作者：
C. Hammond;F. Jelovsek;Kerry L Lee;W. Creasman;R. T. Parker
对两组雌激素水平低下的妇女进行回顾性比较分析。由一组医生对患者进行了至少五年的观察-- 301名接受替代雌激素治疗的患者和309名未经治疗的患者。每组中，207名妇女原位子宫。将两组之间肿瘤（妇科、乳腺和所有部位）的发病率数据与第三次全国癌症调查进行比较，得出雌激素治疗妇女子宫内膜腺癌发生的风险比分别为3.8和9.3。在任何其他恶性肿瘤中没有增加。在雌激素治疗中加入合成的孕激素对子宫内膜癌的发生提供了显著的保护作用，并且没有减少先前报道的雌激素治疗的代谢益处。有关雌激素的使用和子宫内膜癌患者的详细资料。
Two groups of hypoestrogenic women are analyzed by retrospective comparison. Patients were observed by a single group of physicians for at least five years -- 301 patients treated with replacement estrogen and 309 untreated patients. Of each group, 207 women had uteri in situ. Incidence figures for neoplasia (gynecologic, breast, and all sites) were compared between the two groups and with the Third National Cancer Survey, yielding a risk ratio for the development of adenocarcinoma of the endometrium among estrogen-treated women of 3.8 and 9.3, respectively. There was no increase among any other malignancies. The addition of synthetic progestin to estrogen therapy provided significant protection against the likelihood of developing endometrial cancer and did not reduce previously reported metabolic benefits of estrogen treatment. Data pertaining to estrogen use and details of the patients with endometrial carcinoma are presented.