New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group.
New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group.
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DOI：
10.1161/circulationaha.113.007980
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发表时间：
2014-07-01
期刊：
影响因子：
37.8
通讯作者：
Redington AN
中科院分区：
文献类型：
--
作者：
Burns KM;Byrne BJ;Gelb BD;Kühn B;Leinwand LA;Mital S;Pearson GD;Rodefeld M;Rossano JW;Stauffer BL;Taylor MD;Towbin JA;Redington AN
小儿心力衰竭（HF）是指婴儿、儿童或青少年的心脏无法满足身体的代谢需求。它涉及循环、神经体液和分子异常，表现为水肿、呼吸窘迫、生长衰竭和运动不耐受。无数的原因包括遗传性和获得性心肌异常（心肌病[CM]）、容量超负荷（心内分流、瓣膜返流）和功能性单心室预测的独特血流动力学（姑息性复杂先天性心脏病[CHD]）。尽管成人HF的社会和经济成本众所周知，但儿科HF的负担不太熟悉，但也不轻。需要住院治疗的新发HF发生率为0.87/100 000儿童，1但这不包括不断增长的CHD相关HF人群。2006年，美国有近14000例儿科因各种原因的HF住院治疗。2 HF相关入院率接近18/100000儿童，2与严重脓毒症相当。3
Pediatric heart failure (HF) is the inability of the heart of an infant, child, or adolescent to meet the body’s metabolic demands. It involves circulatory, neurohumoral, and molecular abnormalities that manifest as edema, respiratory distress, growth failure, and exercise intolerance. The myriad causes include inherited and acquired myocardial anomalies (cardiomyopathy [CM]), volume overload (intracardiac shunts, valvular regurgitation), and the unique hemodynamics predicated by a functional single ventricle (palliated complex congenital heart disease [CHD]).Although the societal and financial costs of adult HF are well known, the burden of pediatric HF is less familiar, but no less onerous. New-onset HF requiring hospital admission occurs in 0.87 per 100 000 children, 1 yet that does not include the growing population with CHD-related HF. In 2006, there were nearly 14 000 pediatric hospitalizations for HF from all causes in the United States. 2 The rate of HF-related admissions was nearly 18 per 100 000 children, 2 which is comparable to severe sepsis. 3