How Actin Tracks Affect Myosin Motors.
How Actin Tracks Affect Myosin Motors.
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肌动蛋白轨迹如何影响肌球蛋白运动。
DOI：
10.1007/978-3-030-38062-5_9
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发表时间：
2020
影响因子：
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通讯作者：
Rock,RonaldS
中科院分区：
文献类型：
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作者：
Santos,Alicja;Shauchuk,Yauhen;Cichoń,Urszula;Vavra,KevinC;Rock,RonaldS
通过细胞骨架运输的细胞组织是一个至关重要的过程。高度专业化的系统进化，使电机能够识别和选择运动的最佳轨道。在本章中，我们研究了肌动蛋白丝网络对肌凝蛋白运动模式的深远影响。我们认为，肌凝蛋白类具有适应性，使它们能够检测肌动蛋白上的局部结构和化学线索。这些线索通常以连贯的方式排列在肌动蛋白丝网络上，允许远距离定向运输。我们确定了许多潜在的重要线索，从肌动蛋白亚基的生化状态一直到多丝网络和束。
Cellular organization through cytoskeletal trafficking is a process of fundamental importance. Highly specialized systems evolved that enable motors to identify and select the optimal tracks for motility. In this chapter, we examine the profound effect of actin filament networks on myosin motility patterns. We argue that the myosin classes have adaptations that allow them to detect local structural and chemical cues on actin. These cues are often arranged in a coherent manner on actin filament networks, allowing for directed transport over long distances. We identify a number of potentially important cues, ranging from the biochemical states of actin subunits all the way to multi-filament networks and bundles.