Photoreceptor metabolic reprogramming: current understanding and therapeutic implications.
Photoreceptor metabolic reprogramming: current understanding and therapeutic implications.
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DOI：
10.1038/s42003-021-01765-3
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发表时间：
2021-02-24
影响因子：
5.9
通讯作者：
Besirli CG
中科院分区：
文献类型：
--
作者：
Pan WW;Wubben TJ;Besirli CG
获得性和遗传性视网膜疾病导致全世界越来越多的人视力丧失。光感受器（PR）死亡是这些不同视网膜疾病导致的视力丧失的核心。不幸的是，缺乏防止 PR 丧失的治疗选择，因此对改善 PR 存活率并最终改善视力的治疗存在迫切的未满足需求。视网膜是体内最需要能量的组织之一，这在很大程度上是由 PR 的代谢需求驱动的。最近的研究表明，营养物质可用性的破坏和细胞代谢的调节可能是 PR 死亡的统一机制。了解视网膜细胞代谢及其在疾病中如何改变已被确定为优先研究领域。本综述的重点是了解 PR 代谢的最新进展，以及它对氧化还原 (redox) 平衡、视网膜外代谢生态系统和视网膜疾病的重要性。这些代谢过程的重要性才刚刚开始被认识到，解开 PR 健康不可或缺的代谢和氧化还原途径可能会确定神经保护策略的新目标，以防止异质性视网膜疾病组失明。光感受器死亡是各种视网膜疾病中视力丧失的核心。营养供应和细胞代谢的破坏可能是光感受器死亡的原因。在这篇评论中，潘等人。重点关注光感受器代谢的最新进展，并提出预防失明的神经保护策略的新靶标。
Acquired and inherited retinal disorders are responsible for vision loss in an increasing proportion of individuals worldwide. Photoreceptor (PR) death is central to the vision loss individuals experience in these various retinal diseases. Unfortunately, there is a lack of treatment options to prevent PR loss, so an urgent unmet need exists for therapies that improve PR survival and ultimately, vision. The retina is one of the most energy demanding tissues in the body, and this is driven in large part by the metabolic needs of PRs. Recent studies suggest that disruption of nutrient availability and regulation of cell metabolism may be a unifying mechanism in PR death. Understanding retinal cell metabolism and how it is altered in disease has been identified as a priority area of research. The focus of this review is on the recent advances in the understanding of PR metabolism and how it is critical to reduction-oxidation (redox) balance, the outer retinal metabolic ecosystem, and retinal disease. The importance of these metabolic processes is just beginning to be realized and unraveling the metabolic and redox pathways integral to PR health may identify novel targets for neuroprotective strategies that prevent blindness in the heterogenous group of retinal disorders. Photoreceptor death is central to vision loss in various retinal diseases. Disruption of nutrient availability and cell metabolism may underlie photoreceptor death. In this review, Pan et al. focus on the recent advances in the understanding of photoreceptor metabolism and suggest novel targets for neuroprotective strategies that prevent blindness.
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DOI：
10.1186/2046-2395-3-6
发表时间：
2014
期刊：
Longevity & healthspan
影响因子：
--
作者：
Dai DF;Chiao YA;Marcinek DJ;Szeto HH;Rabinovitch PS
通讯作者：
Rabinovitch PS
影响因子：
3.5
作者：
Bryan, John M.;Fufa, Temesgen D.;McGaughey, David M.
通讯作者：
McGaughey, David M.
影响因子：
5.5
作者：
Daniele, Lauren L.;Sauer, Brian;Philp, Nancy J.
通讯作者：
Philp, Nancy J.
丙酮酸激酶M2激活剂促进四聚体形成并抑制肿瘤发生。
影响因子：
14.8
作者：
Anastasiou, Dimitrios;Yu, Yimin;Israelsen, William J.;Jiang, Jian-Kang;Boxer, Matthew B.;Hong, Bum Soo;Tempel, Wolfram;Dimov, Svetoslav;Shen, Min;Jha, Abhishek;Yang, Hua;Mattaini, Katherine R.;Metallo, Christian M.;Fiske, Brian P.;Courtney, Kevin D.;Malstrom, Scott;Khan, Tahsin M.;Kung, Charles;Skoumbourdis, Amanda P.;Veith, Henrike;Southall, Noel;Walsh, Martin J.;Brimacombe, Kyle R.;Leister, William;Lunt, Sophia Y.;Johnson, Zachary R.;Yen, Katharine E.;Kunii, Kaiko;Davidson, Shawn M.;Christofk, Heather R.;Austin, Christopher P.;Inglese, James;Harris, Marian H.;Asara, John M.;Stephanopoulos, Gregory;Salituro, Francesco G.;Jin, Shengfang;Dang, Lenny;Auld, Douglas S.;Park, Hee-Won;Cantley, Lewis C.;Thomas, Craig J.;Heiden, Matthew G. Vander
通讯作者：
Heiden, Matthew G. Vander
影响因子：
4.4
作者：
Curcio CA
通讯作者：
Curcio CA