Chemical Tools To Monitor and Manipulate Adaptive Immune Responses.
Chemical Tools To Monitor and Manipulate Adaptive Immune Responses.
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DOI：
10.1021/jacs.6b02954
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发表时间：
2016-05-18
影响因子：
15
通讯作者：
Kodadek T
中科院分区：
文献类型：
--
作者：
Doran TM;Sarkar M;Kodadek T
监测和操纵免疫系统的方法具有巨大的临床意义。例如，疫苗的开发是生物医学研究企业最早和最伟大的成就之一。最近，能够“唤醒”癌症免疫系统的药物引起了巨大的兴奋。但是，仍有许多工作要做。今天所有可用的操纵免疫系统的药物都不能区分“好”和“坏”的免疫反应，从而驱动全身和全身免疫抑制或激活。事实上，除了疫苗之外，我们监测和操纵抗原特异性免疫反应的能力还处于起步阶段。实现这种更精细的控制水平是非常可取的。例如，它可能允许致病性免疫反应的药理学编辑，而不限制免疫系统防御感染的能力。在诊断方面，全面监测循环的抗原特异性抗体群体的方法可以提供临床上有用的生物标志物的宝库，因为许多疾病使免疫系统暴露于被认为是外来的特征分子并引发针对它们的抗体的产生。这一观点将讨论这一领域的最新技术，重点是我们认为化学界为这一重要领域做出贡献的开创性机会。
Methods to monitor and manipulate the immune system are of enormous clinical interest. For example, the development of vaccines represents one of the earliest and greatest accomplishments of the biomedical research enterprise. More recently, drugs capable of “reawakening” the immune system to cancer have generated enormous excitement. But, much remains to be done. All drugs available today that manipulate the immune system cannot distinguish between “good” and “bad” immune responses and thus drive general and systemic immune suppression or activation. Indeed, with the notable exception of vaccines, our ability to monitor and manipulate antigen-specific immune responses is in its infancy. Achieving this finer level of control would be highly desirable. For example, it might allow the pharmacological editing of pathogenic immune responses without restricting the ability of the immune system to defend against infection. On the diagnostic side, a method to comprehensivel y monitor the circulating, antigen-specific antibody population could provide a treasure trove of clinically useful biomarkers, since many diseases expose the immune system to characteristic molecules that are deemed foreign and elicit the production of antibodies against them. This perspective will discuss the state-of-the-art of this area with a focus on what we consider seminal opportunities for the chemistry community to contribute to this important field.