AN IRON CARBOXYLATE BOND LINKS THE HEME UNITS OF MALARIA PIGMENT
AN IRON CARBOXYLATE BOND LINKS THE HEME UNITS OF MALARIA PIGMENT
复制标题
DOI：
10.1073/pnas.88.2.325
复制
发表时间：
1991-01-01
影响因子：
11.1
通讯作者：
HENDERSON, GB
中科院分区：
文献类型：
--
作者：
SLATER, AFG;SWIGGARD, WJ;HENDERSON, GB
红细胞内疟疾寄生虫使用血红蛋白作为主要营养源。 血红蛋白的消化释放出血红素，寄生虫将其转化为一种不溶性微晶材料，称为疟原虫色素或疟疾色素。 我们从人类疟原虫恶性疟原虫中纯化了疟原虫色素，并使用红外光谱、X 射线吸收光谱和化学合成来确定其结构。 该分子由一种不寻常的血红素聚合物组成，该聚合物连接在一个血红素的中心铁离子和另一个血红素的羧酸侧基氧之间。 血红素通过这种连接被隔离成不溶性产物，为疟原虫提供了一种独特的方式来避免与可溶性血红素相关的毒性。
The intraerythrocytic malaria parasite uses hemoglobin as a major nutrient source. Digestion of hemoglobin releases heme, which the parasite converts into an insoluble microcrystalline material called hemozoin or malaria pigment. We have purified hemozoin from the human malaria organism Plasmodium falciparum and have used infrared spectroscopy, x-ray absorption spectroscopy, and chemical synthesis to determine its structure. The molecule consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another. The hemes are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme.