Regarding mutagenic mucus in the cervix of smokers.
Regarding mutagenic mucus in the cervix of smokers.
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关于吸烟者子宫颈中的致突变粘液。
DOI：
10.1093/jnci/78.3.590
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Felton
中科院分区：
文献类型：
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作者：
M. Schiffman;L. Brinton;E. Holly;L. Lannom;R. Kurman;W. Lancaster;A. W. Andrews;J. Felton
先生：霍莉等人。1最近报道在宫颈粘液中发现了与吸烟相关的诱变活性。在36名当前吸烟者中，39%的人突变测试呈阳性，而42名不吸烟者中的这一比例为12%。吸烟对宫颈粘液的影响可能有助于解释一些流行病学调查中发现的吸烟与宫颈肿瘤之间的联系。因此，作为正在进行的宫颈异型增生流行病学调查的一部分，我们使用了与Holly等人相同的收集方法和突变分析。1对55名在乔治敦大学医院妇产科诊所进行常规巴氏涂片检查的妇女进行宫颈粘液检测。我们报告的发现可能会改变Holly等人对吸烟效应的解释。1我们研究的女性年龄从19岁到75岁(平均30岁)。55%的女性是黑人，其余的是白人。在样本收集时，20%的女性已经怀孕。我们故意对吸烟者进行过抽样，因此我们研究组中当前吸烟的比例(65%)被人为提高。
SIR: Holly et al. 1 recently reported finding smokingrelated mutagenic activity in cervical mucus. Of 36 current smokers, 39% had positive mutagenicity tests, compared to 12% of 42 nonsmokers. An effect of smoking on cervical mucus might help to explain the association between smoking and cervical neoplasia seen in some epidemiologic investigations. Consequently, as part of an ongoing epidemiologic investigation of cervical dysplasia, we used the same collection method and mutagenicity assay as Holly et al. 1 to test cervical mucus from 55 women obtaining routine Pap smears at the Georgetown University Hospital Obstetrics and Gynecology Clinics. We report findings that may alter the interpretation of the smoking effect found by Holly et al. 1The women in our study ranged in age from 19 to 75 years old (mean, 30 yr). Fifty-five percent of the women were black; the remainder were white. Twenty percent of the women were pregnant at the time of sample collection. We purposefully oversampled smokers, so the proportion of current smoking in our study group (65%) was artificially elevated.