Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma
Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma
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DOI：
10.1016/j.jaip.2022.11.025
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发表时间：
2023-03-07
影响因子：
9.4
通讯作者：
Ilmarinen，Pinja
中科院分区：
文献类型：
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作者：
Flinkman，Ella;Vahatalo，Iida;Ilmarinen，Pinja
背景哮喘是一种疾病，根据临床特征和发病的分子机制，可分为不同的表型和内源性，本研究的目的是评估成人非小细胞肺癌患者血嗜酸性粒细胞和中性粒细胞计数与临床和分子特征之间的关系。发病哮喘。Methodsblood嗜酸性粒细胞和中性粒细胞计数测定203例谁参加了Seinäjoki成人哮喘研究，并参加了12年的随访。根据嗜酸性粒细胞和中性粒细胞水平将患者分为4组（少粒细胞组（n = 108）、嗜酸性粒细胞组（n = 60）、嗜酸性粒细胞组（n = 21）和混合粒细胞组（n = 14））。用于定义组的截止值为0.30×109·L-1的血液嗜酸性粒细胞和4.4×109·L-1的血液中性粒细胞。结果中性粒细胞组有最高的BMI，分配最高剂量的吸入性皮质类固醇在12年的后续行动，并作出最计划外的呼吸访问。中性粒细胞、嗜酸性粒细胞和混合粒细胞组较少粒细胞组哮喘严重。中性粒细胞和嗜酸性粒细胞组与较高的分配抗生素。嗜酸性粒细胞组有更多的鼻息肉，更多的疑似鼻窦炎，肺功能更大的下降，骨膜蛋白，呼出气一氧化氮和免疫球蛋白E的水平增加。中性粒细胞组高敏C反应蛋白、基质金属蛋白酶9、白细胞介素6、瘦素和可溶性尿激酶型纤溶酶原激活物受体水平升高。混合性粒细胞组表现出增加的Escherichiophilic group.ConclusionsIn除了血嗜酸性粒细胞，也血中性粒细胞计数反映了潜在的炎症模式，并表明哮喘的临床特征和结果的重要差异。
BackgroundAsthma is a disease that can be separated into different phenotypes and endotypes based on the clinical characteristics and the molecular mechanisms of the condition, respectively.ObjectiveThe aim of this study is to assess the association between blood eosinophil and neutrophil counts with clinical and molecular features in patients with adult-onset asthma.MethodsBlood eosinophil and neutrophil counts were measured from 203 patients who took part in the Seinäjoki Adult Asthma Study and attended the 12-year follow-up visit. The patients were then divided into four groups (paucigranulocytic (n = 108), neutrophilic (n = 60), eosinophilic (n = 21) and mixed granulocytic (n = 14)) according to eosinophil and neutrophil levels. The cut-off values used to define the groups were 0.30×109·L−1for blood eosinophils and 4.4×109·L−1for blood neutrophils.ResultsNeutrophilic group had highest BMI, was dispensed the highest doses of inhaled corticosteroids during the 12-year follow-up and made most unplanned respiratory visits. Neutrophilic, eosinophilic and mixed granulocytic groups had more severe asthma compared to paucigranulocytic group. Neutrophilic and eosinophilic groups were associated with higher dispensed antibiotics. Eosinophilic group had more nasal polyps, more suspected sinusitis, greater decline in lung function, and increased levels of periostin, fraction of exhaled nitric oxide and immunoglobulin E. Neutrophilic group had increased high-sensitivity C-reactive protein, matrix metalloproteinase-9, interleukin-6, leptin and soluble urokinase plasminogen activator receptor levels. Mixed granulocytic group showed increased resistin levels together with neutrophilic group.ConclusionsIn addition to blood eosinophil, also blood neutrophil counts reflect the underlying inflammatory pattern and indicate important differences in asthma clinical features and outcomes.