Blood perfusion and transcutaneous oxygen level characterizations in human skin with changes in normal and shear loads - Implications for pressure ulcer formation
Blood perfusion and transcutaneous oxygen level characterizations in human skin with changes in normal and shear loads - Implications for pressure ulcer formation
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DOI：
10.1016/j.clinbiomech.2010.06.003
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发表时间：
2010-10-01
影响因子：
1.8
通讯作者：
Bush, Tamara Reid
中科院分区：
文献类型：
--
作者：
Manorama, Abinand Anbazhagan;Baek, Seungik;Bush, Tamara Reid
背景：褥疮（压力性溃疡）是皮肤及其下层组织破裂的局部区域。褥疮每年影响美国约300万人，包括老年人，糖尿病患者和长期坐轮椅的人。实验研究表明，静态或动态的正常负荷会导致皮肤中的血液闭塞，而长时间的负荷条件会导致皮肤损伤。然而，很少有研究报告的影响，“正常和剪切”联合负荷对血液灌注。本研究的目的是研究正常和剪切loaded.Methods时，在人体皮肤的经皮氧水平和血液灌注的改变：15人受试者进行了评估，在7个不同的条件下，在正常和剪切加载的前臂应用程序的经皮氧和血液灌注水平的变化。经皮氧水平和血液灌注连续测量使用激光多普勒系统，而施加的力量进行了量化与多轴负荷cell.Findings：经皮氧和血液灌注水平下降时，除了正常的负荷施加剪切负荷。此外，从第一个到最后一个测试条件，恢复期期间的血液灌注逐渐增加。解释：结果表明，增加剪切载荷降低了皮肤中的经皮氧和血液灌注水平。基于这些发现，剪切力可能在皮肤损伤中起作用，当试图防止溃疡发展时，应考虑剪切力和正常载荷。(C)2010爱思唯尔有限公司保留所有权利。
Background: Decubitus ulcers (pressure ulcers) are localized areas of tissue breakdown in the skin and the underlying regions. Decubitus ulcers affect approximately 3 million people in the USA every year, including seniors, individuals with diabetes, and those who spend long periods in wheelchairs. Experimental studies demonstrate that static or dynamic normal loads cause blood occlusion in the skin, while prolonged loading conditions can result in skin damage. However, few studies report the effects of 'normal and shear' combined loading on blood perfusion. The goal of this research was to study alterations of transcutaneous oxygen levels and blood perfusion in human skin when both normal and shear loads were applied.Methods: Fifteen human subjects were evaluated under seven different conditions for changes in transcutaneous oxygen and blood perfusion levels during applications of normal and shear loading on the forearm. Transcutaneous oxygen levels and blood perfusion were continuously measured using a Laser Doppler system, while applied forces were quantified with a multi-axis load cell.Findings: Transcutaneous oxygen and blood perfusion levels decreased when shear loads were applied in addition to normal loads. Further, blood perfusion during recovery periods increased gradually from the first to the last test condition. Interpretation: Results indicate that adding shear loads decreased transcutaneous oxygen and blood perfusion levels in the skin. Based on these findings, shear force may play a role in skin damage, and both shear and normal loads should be considered when trying to prevent ulcer development. (C) 2010 Elsevier Ltd. All rights reserved.