Reduction of self-diffusion coefficient in a coarse-grained model of cytoplasm
Reduction of self-diffusion coefficient in a coarse-grained model of cytoplasm
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DOI：
10.1103/physrevresearch.2.013279
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发表时间：
2020-03-09
影响因子：
4.2
通讯作者：
Miyaguchi, Tomoshige
中科院分区：
文献类型：
--
作者：
Miyaguchi, Tomoshige
对具有和不具有流体动力学相互作用的多分散硬球悬浮液的理论预测应用于细菌细胞质的粗粒度模型，该模型由 15 种球形颗粒组成。获得了每种物质的一阶浓度的短时和长时间自扩散系数。研究表明，流体动力相互作用会导致绿色荧光蛋白等小颗粒的扩散率大幅降低。此外，还提出了对上述理论的启发式修改，使其在更高浓度下有效。
Theoretical predictions for polydisperse hard-sphere suspensions with and without hydrodynamic interaction are applied to a coarse-grained model of bacterial cytoplasm, which consists of 15 species of spherical particles. Short-time and long-time self-diffusion coefficients of each species are obtained to the first order in concentration. It is shown that the hydrodynamic interaction leads to a large reduction of diffusivity for small particles such as green fluorescent proteins. Moreover, a heuristic modification of the above theory to make it valid at higher concentrations is presented.