Recruiting for epigenetic research: facilitating the informed consent process.
Recruiting for epigenetic research: facilitating the informed consent process.
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表观遗传学研究招募：促进知情同意过程。
DOI：
10.1155/2013/935740
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发表时间：
2013
影响因子：
1.9
通讯作者：
Jackson-Cook,Colleen
中科院分区：
文献类型：
--
作者：
Jallo,Nancy;Lyon,DebraE;Kinser,PatriciaAnne;Kelly,DebraLynch;Menzies,Victoria;Jackson-Cook,Colleen
由于表观遗传（基因-环境相互作用）变化的影响与许多不良健康状态有关，表观遗传措施的研究为生物行为科学家提供了令人兴奋的研究机会。然而，为专注于遗传学任何方面的研究招募人员都面临挑战。包括缺乏对研究的了解在内的多种因素已被确定为征聘的障碍。通过广泛的讨论加强知情同意过程被认为是有效的招募研究一般，但有一个缺乏的信息，集中在这样的招募策略表观遗传学研究。 在本文中，我们分享了我们的经验与战略，以加强知情同意过程，以及提供样本的材料开发，以提高潜在的参与者的表观遗传学的理解，在4个表观遗传学研究与妇女来自不同背景经历了一系列的健康问题。使用该过程的表观遗传学研究的合并入组成功率为89%，参与者代表不同的人群。 我们认为，精心制定的招聘脚本为提高潜在参与者对研究项目的理解提供了基础。易于理解的表观遗传过程的插图为积极参与提供了基础，并鼓励个人提出问题。
Because the effects of epigenetic (gene‐environment interaction) changes have been associated with numerous adverse health states, the study of epigenetic measures provides exciting research opportunities for biobehavioral scientists. However, recruitment for studies focusing on any aspect of genetics poses challenges. Multiple factors, including lack of knowledge regarding a research study, have been identified as barriers to recruitment. Strengthening the informed consent process through extended discussion has been found to be effective in recruiting for research studies in general, yet there is a paucity of information that focused on such a recruitment strategy for epigenetic studies. In this paper, we share our experiences with strategies to strengthen the informed consent process as well as provide samples of materials developed to heighten potential participants’ understanding of epigenetics, in 4 epigenetic research studies with women from diverse backgrounds experiencing a range of health issues. The combined enrollment success rate for epigenetic studies using the process was 89% with participants representing a diverse population. We posit that carefully developed recruitment scripts provided a foundation for improving potential participants’ understanding of the research project. Easy to understand illustrations of the epigenetic process provided a basis for active engagement and encouraged individual questions.