Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring
Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring
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DOI：
10.1038/nchembio.331
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发表时间：
2010-04-01
影响因子：
14.8
通讯作者：
Svatos, Ales
中科院分区：
文献类型：
--
作者：
Kroiss, Johannes;Kaltenpoth, Martin;Svatos, Ales
蜂狼挖掘黄蜂培养特定的共生细菌（链霉菌属），这些细菌被纳入幼虫茧中以抵御病原体。我们确定了自然环境中这种保护性共生的分子基础，并证明细菌产生了九种抗生素物质的“鸡尾酒”。所有共生体产生的抗生素的互补作用为黄蜂幼虫提供了有效的抗菌防御，这与人类医学中已知的“联合预防”相似。
Beewolf digger wasps cultivate specific symbiotic bacteria (Streptomyces spp.) that are incorporated into the larval cocoon for protection against pathogens. We identified the molecular basis of this protective symbiosis in the natural context and demonstrate that the bacteria produce a 'cocktail' of nine antibiotic substances. The complementary action of all symbiont-produced antibiotics confers a potent antimicrobial defense for the wasp larvae that parallels the 'combination prophylaxis' known from human medicine.