Treatment Outcomes and Associated Factors in Tuberculosis Patients at Atwima Nwabiagya District, Ashanti Region, Ghana: A Ten-Year Retrospective Study.
Treatment Outcomes and Associated Factors in Tuberculosis Patients at Atwima Nwabiagya District, Ashanti Region, Ghana: A Ten-Year Retrospective Study.
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DOI：
10.1155/2021/9952806
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发表时间：
2021
影响因子：
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通讯作者：
Yeboah EO
中科院分区：
文献类型：
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作者：
Agyare SA;Osei FA;Odoom SF;Mensah NK;Amanor E;Martyn-Dickens C;Owusu-Ansah M;Mohammed A;Yeboah EO
结核病对地球仪各地的公共卫生构成巨大威胁，而且大多数人都处于生产年龄，尽管如此;每个人都容易感染结核病。为了评估结核病控制项目活动的有效性和绩效，治疗成功的病例百分比是关键。为了控制结核病，通过有效治疗阻断传播，怎么强调都不为过。该研究旨在确定2007-2017年Atwima Nwabiagya地区与结核病治疗结果相关的因素。 2007年1月至2017年12月，在Atwima Nwabiagya区的五个直接观察治疗短程（DOTS）中心对常规/标准结核病登记进行了回顾性审查。评估了人口统计学特征、临床特征和治疗结局。进行双变量和多变量logistic回归以确定成功治疗结果的预测因素。 在该地区评估的891名结核病患者中，治疗成功率为68.46%。患者，年龄≤ 20岁（调整后的比值比（aOR）= 4.74，95%CI = 1.75 - 12.83）和51-60岁（aOR = 1.94，95%CI = 1.12 − 3.39），治疗前体重为35-45 kg（aOR = 2.54，95%CI = 1.32 − 4.87）、46-55 kg（aOR = 2.75，95%CI = 1.44 − 5.27）和56-65 kg（aOR = 3.04，95%CI = 1.50 − 6.14）与治疗成功相关。然而，重新治疗患者（aOR = 0.31，95%CI = 0.11 − 0.84）导致治疗结局不成功。 结核病患者的成功治疗结果分别比全国平均治疗成功率和世卫组织目标低约20.00%和30.00%。对复治患者和高龄患者的积极监测、激励和咨询是治疗成功的关键。
Tuberculosis poses a great threat to public health around the globe and affects persons mostly in their productive age, notwithstanding; everyone is susceptible to tuberculosis (TB) infection. To assess the effectiveness and performance of the tuberculosis control program activities, the percentage of cases with treatment success outcome is key. To control tuberculosis, interrupting transmission through effective treatment cannot be overemphasized. The study was conducted to determine factors associated with TB treatment outcome, in the Atwima Nwabiagya District from 2007–2017. A Retrospective review of routine/standard TB registers was carried out in five directly observed therapy short-course (DOTS) centres at the Atwima Nwabiagya District from January 2007 to December 2017. Demographic characteristics, clinical characteristics, and treatment outcomes were assessed. Bivariate and multivariate logistic regression was conducted to determine the predictors of successful treatment outcome. Of the 891 TB client's data that was assessed in the district, the treatment success rate was 68.46%. Patients, aged ≤ 20 years (adjusted odds ratio (aOR) = 4.74, 95%CI = 1.75 − 12.83) and 51-60 years (aOR = 1.94, 95%CI = 1.12 − 3.39), having a pretreatment weight of 35-45 kg (aOR = 2.54, 95%CI = 1.32 − 4.87), 46-55 kg (aOR = 2.75, 95%CI = 1.44 − 5.27) and 56-65 kg (aOR = 3.04, 95%CI = 1.50 − 6.14) were associated with treatment success. However, retreatment patients (aOR = 0.31, 95%CI = 0.11 − 0.84) resulted in unsuccessful treatment outcome. Successful treatment outcome among TB patients was about 20.00% and 30.00% lower compared to the national average treatment success rate and WHO target, respectively. Active monitoring, motivation, and counselling of retreatment patients and patients with advanced age are key to treatment success.