Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma
Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma
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DOI：
10.1158/1078-0432.ccr-05-0857
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发表时间：
2006-02-01
影响因子：
11.5
通讯作者：
Noessner, E
中科院分区：
文献类型：
--
作者：
Schleypen, JS;Baur, N;Noessner, E
目的：肾细胞癌具有大量的浸润性淋巴细胞，对肿瘤的控制效果明显有限。本研究旨在探讨肾细胞癌中自然杀伤（NK）细胞的浸润情况。实验设计：从肾细胞癌中分离肿瘤浸润淋巴细胞（TIL），分析NK细胞的频率和表型（n = 34）。结果：两种肾细胞癌亚型，一种含有高（>20%的淋巴细胞群体，n = 14），另一种含有低（>20%的淋巴细胞群体，n = 14），
Purpose: Renal cell carcinoma harbors high numbers of infiltrating lymphocytes with apparent limited efficacy in tumor control. This study focused on the natural killer (NK) cells infiltrating renal cell carcinoma.Experimental Design: Tumor-infiltrating lymphocytes (TIL) were isolated from renal cell carcinoma and analyzed for NK cell frequency and phenotype (n = 34). NK cells were enriched and tested for effector function.Results: Two renal cell carcinoma subtypes were identified, one containing high (>20% of the lymphocyte population, n = 14), the other low (