Complement Complex C5b-9 Levels Are Associated with the Clinical Outcomes of Acute Ischemic Stroke and Carotid Plaque Stability.
Complement Complex C5b-9 Levels Are Associated with the Clinical Outcomes of Acute Ischemic Stroke and Carotid Plaque Stability.
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补体复杂的C5B-9水平与急性缺血性中风和颈动脉斑块稳定性的临床结果有关。
DOI：
10.1007/s12975-018-0658-3
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发表时间：
2019-06
影响因子：
6.9
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Si W;He P;Wang Y;Fu Y;Li X;Lin X;Chen F;Cao G;Zhang H
补体终末复合物C5 b-9在急性缺血性卒中（AIS）和颈动脉粥样硬化中起重要作用。然而，血清C5 b-9、AIS的严重程度和结局以及颈动脉斑块的稳定性之间的关系尚未得到很好的研究。在这项临床研究中，招募了70名AIS患者和70名健康对照。采用酶联免疫吸附试验（ELISA）测定脑卒中后72 h血清C5 b-9水平。评估颈动脉大小、美国国立卫生研究院卒中量表（NIHSS）、90天改良兰金量表（mRS）、颈动脉斑块和狭窄。AIS患者的血清C5 b-9水平显著高于健康对照组（p < 0.001），并与梗死面积（p = 0.045）和NIHSS（P = 0.035）相关。90 d mRS分析结果显示，预后差的患者血清C5 b-9水平高于预后好的患者（P < 0.001）。AIS患者颈动脉斑块不稳定组血清C5 b-9水平明显高于颈动脉斑块稳定组（P = 0.009）。多因素Logistic回归分析显示，C5 b-9可能是AIS（P < 0.001）和颈动脉不稳定斑块（P = 0.015）的独立危险因素。因此，补体复合物C5 b-9可能是预测AIS患者颈动脉斑块严重程度和结局以及稳定性的潜在生物标志物。
The terminal complement complex C5b-9 plays an important role in acute ischemic stroke (AIS) and carotid atherosclerosis. However, the associations between serum C5b-9, the severity and outcome of AIS, and the stability of carotid plaques have not been well investigated. In this clinical study, 70 patients with AIS and 70 healthy controls were enrolled. Serum C5b-9 levels at 72 h after stroke onset were measured by enzyme-linked immunosorbent assay (ELISA). Infarct size, the National Institutes of Health Stroke Scale (NIHSS), the 90-day modified Rankin Scale (mRS), and carotid plaque and stenosis were evaluated. Serum C5b-9 levels were significantly higher in AIS patients than in healthy controls (p < 0.001) and were correlated with infarction sizes (p = 0.045) and the NIHSS (P = 0.035). Furthermore, 90-day mRS analysis demonstrated that the patients with poor outcomes had higher serum C5b-9 levels than those with good outcomes (P < 0.001). Moreover, serum C5b-9 levels in AIS patients with unstable carotid plaques were much higher than in those with stable carotid plaques (P = 0.009). Multivariate logistic regression indicated that C5b-9 could be an independent risk factor for AIS (P < 0.001) and unstable carotid plaques (P = 0.015). Therefore, complement complex C5b-9 may be a potential biomarker in predicting the severity and outcome, as well as the stability of carotid plaques, in AIS patients.
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影响因子：
2.6
作者：
Tuboly E;Futakuchi M;Varga G;Érces D;Tőkés T;Mészáros A;Kaszaki J;Suzui M;Imai M;Okada A;Okada N;Boros M;Okada H
通讯作者：
Okada H
影响因子：
5.3
作者：
Oksjoki, Riina;Kovanen, Petri T.;Pentikainen, Markku O.
通讯作者：
Pentikainen, Markku O.
影响因子：
8.3
作者：
Gelderblom, Mathias;Leypoldt, Frank;Magnus, Tim
通讯作者：
Magnus, Tim
影响因子：
4.4
作者：
Bossi, F;Fischetti, F;Tedesco, F
通讯作者：
Tedesco, F
影响因子：
4.4
作者：
Tegla, Cosmin A.;Cudrici, Cornelia;Patel, Snehal;Trippe, Richard, III;Rus, Violeta;Niculescu, Florin;Rus, Horea
通讯作者：
Rus, Horea