GSK-3β: A Bifunctional Role in Cell Death Pathways.
GSK-3β: A Bifunctional Role in Cell Death Pathways.
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DOI：
10.1155/2012/930710
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发表时间：
2012
影响因子：
--
通讯作者：
Thotala D
中科院分区：
文献类型：
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作者：
Jacobs KM;Bhave SR;Ferraro DJ;Jaboin JJ;Hallahan DE;Thotala D
虽然糖原合成酶激酶-3 β（GSK-3β）最初因其磷酸化糖原合成酶和调节葡萄糖代谢的能力而命名，但目前已知这种多功能激酶是广泛细胞功能的关键调节剂。GSK-3β参与调节多种功能，包括细胞信号传导、生长代谢和决定生物体存活或死亡的各种转录因子。继GSK-3β在包括阿尔茨海默病、炎症、糖尿病和癌症在内的各种疾病中的作用之后，GSK-3β的小分子抑制剂正获得显著关注。本文主要关注GSK-3β在促进细胞存活和凋亡中的双功能或冲突作用。GSK-3β已成为药物开发的重要分子靶点。
Although glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional kinase is presently known to be a key regulator of a wide range of cellular functions. GSK-3β is involved in modulating a variety of functions including cell signaling, growth metabolism, and various transcription factors that determine the survival or death of the organism. Secondary to the role of GSK-3β in various diseases including Alzheimer's disease, inflammation, diabetes, and cancer, small molecule inhibitors of GSK-3β are gaining significant attention. This paper is primarily focused on addressing the bifunctional or conflicting roles of GSK-3β in both the promotion of cell survival and of apoptosis. GSK-3β has emerged as an important molecular target for drug development.