Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications.
Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications.
复制标题
DOI：
10.3390/cells11203214
复制
发表时间：
2022-10-13
期刊：
影响因子：
6
通讯作者：
Bertoletti, Laurent
中科院分区：
文献类型：
--
作者：
Heestermans, Marco;Poenou, Geraldine;Hamzeh-Cognasse, Hind;Cognasse, Fabrice;Bertoletti, Laurent
关键词：
抗凝药物拮抗凝血作用，用于预防或治疗（复发性）静脉血栓栓塞（VTE）。预防凝血的药物已经使用了世纪，如今，医生拥有多种抗凝剂的广泛面板，以满足患者的个性化需求。在这篇综述中，我们的目的是修订目前临床上处方的不同抗凝剂的历史。此外，我们还比较了它们的药理学特性、医学适应症以及在弱势患者人群中应用新抗凝剂的困难。自20世纪30年代引入普通肝素以来，对抗凝剂的机制理解和医疗用途的重大进展使VTE患者的治疗得到了显著改善。然而，新一代抗凝剂目前正在临床试验中进行测试，目的是进一步优化医疗护理。
Anticoagulant drugs antagonize coagulation and are used to prevent or cure (recurrent) venous thromboembolism (VTE). Drugs to prevent clotting have been used for more than a century, and, nowadays, physicians possess a broad panel of multiple anticoagulants to meet the individual needs of a patient. Within this review, we aimed to revise the history of the different anticoagulants that are currently prescribed in the clinic. In addition, we compared their pharmacological properties, medical indications, and the difficulties in implementing new anticoagulants in vulnerable patient populations. Since the introduction of unfractionated heparin in the 1930s, major advances in the mechanistic understanding and the medical use of anticoagulants have allowed for significant improvements to treat VTE patients. However, a new generation of anticoagulants is currently being tested in clinical trials, with the goal of further optimizing medical care.
登录
查看更多内容
影响因子：
5.4
作者：
Chen A;Stecker E;A Warden B
通讯作者：
A Warden B
影响因子：
5.9
作者：
Baillargeon, Jacques;Holmes, Holly M.;Kuo, Yong-Fang
通讯作者：
Kuo, Yong-Fang
影响因子：
4.3
作者：
COUCH, NP
通讯作者：
COUCH, NP
与因子XA抑制剂相关的急性大量出血的Andexanet alfa。
DOI：
10.1056/nejmoa1607887
发表时间：
2016-09-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Connolly SJ;Milling TJ Jr;Eikelboom JW;Gibson CM;Curnutte JT;Gold A;Bronson MD;Lu G;Conley PB;Verhamme P;Schmidt J;Middeldorp S;Cohen AT;Beyer-Westendorf J;Albaladejo P;Lopez-Sendon J;Goodman S;Leeds J;Wiens BL;Siegal DM;Zotova E;Meeks B;Nakamya J;Lim WT;Crowther M;ANNEXA-4 Investigators
通讯作者：
ANNEXA-4 Investigators
影响因子：
6.7
作者：
通讯作者：
--