The many roles of histone deacetylases in development and physiology: implications for disease and therapy.
The many roles of histone deacetylases in development and physiology: implications for disease and therapy.
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DOI：
10.1038/nrg2485
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发表时间：
2009-01
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组蛋白去乙酰化酶（HDAC）是一个庞大的酶家族的一部分，在许多生物过程中具有关键作用，主要是通过其对转录的抑制作用。许多HDAC亚型在真核细胞中的表达引起了关于它们可能的特异性或冗余性的问题，以及它们是否控制基因表达的全局或特定程序。最近对HDAC敲除小鼠的分析揭示了个体HDAC在发育和疾病中的高度特异性功能。缺乏个体HDAC的突变小鼠是用于定义HDAC在体内的功能和HDAC抑制剂在疾病中的分子靶点的有力工具。
Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease.