Clusterin is widely expressed in systemic anaplastic large cell lymphoma but fails to differentiate primary from secondary cutaneous anaplastic large cell lymphoma.
Clusterin is widely expressed in systemic anaplastic large cell lymphoma but fails to differentiate primary from secondary cutaneous anaplastic large cell lymphoma.
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簇蛋白在全身性间变性大细胞淋巴瘤中广泛表达，但无法区分原发性和继发性皮肤间变性大细胞淋巴瘤。
DOI：
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发表时间：
2002
影响因子：
3.5
通讯作者：
W. Macon
中科院分区：
文献类型：
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作者：
M. Laé;I. Ahmed;W. Macon
Wellmann等人最近的一项研究（Blood.二○年; 96：398-404）在所有36个测试的系统性间变性大细胞淋巴瘤（ALCL）中检测到丛生蛋白表达，但在9个原发性皮肤ALCL中的任何一个中都没有。我们的目的是证实clusterin在系统性ALCL中的诊断价值，并评估其在区分原发性皮肤ALCL和继发性皮肤受累的系统性ALCL中的有效性。我们通过石蜡免疫组织化学分析检测了41例系统性ALCL（18例ALK-1+和23例ALK-1-）、9例原发性皮肤ALCL和4例继发性皮肤ALCL中丛生蛋白的表达。在95%（39/41）的系统性ALCL中，包括100%（18/18）的ALK-1+病例和91%（21/23）的ALK-1-病例中，白藜芦醇呈阳性。9例原发性皮肤ALCL中5例（56%）和4例继发性皮肤ALCL中3例（75%）为丛生蛋白阳性。我们的观察证实了clusterin在系统性ALCL中的诊断价值，特别是在ALK-1-病例中。然而，我们的数据未能证明其在区分原发性和继发性皮肤ALCL方面的价值。
A recent study by Wellmann et al (Blood. 2000;96:398-404) detected clusterin expression in all 36 systemic anaplastic large cell lymphomas (ALCLs) tested, but not in any of 9 primary cutaneous ALCLs. Our purpose was to confirm the diagnostic usefulness of clusterin in systemic ALCL and to evaluate its efficacy in distinguishing primary cutaneous ALCL from secondary skin involvement by systemic ALCL. We examined clusterin expression by paraffin immunohistochemical analysis in 41 systemic ALCLs (18 ALK-1+ and 23 ALK-1-), 9 primary cutaneous ALCLs, and 4 secondary cutaneous ALCLs. Clusterin was positive in 95% of systemic ALCLs (39/41), including 100% (18/18) of the ALK-1+ cases and 91% (21/23) of the ALK-1- cases. Five (56%) of 9 primary and 3 (75%) of 4 secondary cutaneous ALCLs were positive for clusterin. Our observations confirm the diagnostic usefulness of clusterin in systemic ALCL, especially in the ALK-1- cases. However, our data fail to demonstrate its value in distinguishing primary from secondary cutaneous ALCL.
使用 cDNA 阵列检测淋巴瘤中差异表达的基因：鉴定簇蛋白作为间变性大细胞淋巴瘤的新诊断标记物。
影响因子：
20.3
作者：
Wellmann,A;Thieblemont,C;Pittaluga,S;Sakai,A;Jaffe,ES;Siebert,P;Raffeld,M
通讯作者：
Raffeld,M