Identification of messenger RNA substrates for mouse T-STAR
Identification of messenger RNA substrates for mouse T-STAR
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DOI：
10.1134/s0006297909110145
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发表时间：
2009-11
期刊：
影响因子：
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通讯作者：
L. Y. Zhang;M. Zeng;P. Chen;H. Sun;D. Tao;Y. Q. Liu;L. Lin;Y. Yang;S. Zhang;Y. Ma
中科院分区：
文献类型：
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作者：
L. Y. Zhang;M. Zeng;P. Chen;H. Sun;D. Tao;Y. Q. Liu;L. Lin;Y. Yang;S. Zhang;Y. Ma
Using the method of isolation of specific nucleic acids associated with proteins (SNAAP), we have identified 10 candidate target mRNA substrates bound by mT-STAR (mouse T-STAR protein) from testis extract. Among them, our study focused onFabp9, a gene that is essential for male gametogenesis, and showed that mT-STAR could directly bind toFabp9mRNAs. The binding sites are in a short sequence of the coding region and 3′ untranslated region ofFabp9mRNA. These suggest that mT-STAR can regulate the metabolism and expression ofFabp9. In conclusion, identification of mT-STAR-bound mRNA substrates might help to illustrate the potential spectrum of the process and provide valuable insight into the biological function of this RNA-binding protein in spermatogenesis.
