c-Fos expression in the cholinergic basal forebrain after enforced wakefulness and recovery sleep
c-Fos expression in the cholinergic basal forebrain after enforced wakefulness and recovery sleep
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DOI：
10.1097/00001756-200002280-00002
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发表时间：
2000-02-28
期刊：
影响因子：
1.7
通讯作者：
Shiromani, PJ
中科院分区：
文献类型：
--
作者：
Greco, MA;Lu, J;Shiromani, PJ
The present study used c-Fos expression to examine cellular activity in cholinergic regions in the basal forebrain (BF) following enforced waking and recovery sleep. Cholinergic cells within the vertical and horizontal limbs of the diagonal band of Broca (VDB acid HDB, respectively) showed significantly higher c-Fos immunoreactivity after prolonged waiting than after recovery sleep. Cholinergic cells within the medial septal nucleus (MS), however, showed no change in c-Fos expression under these conditions. Consistent with our previous findings, c-Fos immunoreactivity in the ventral lateral:preoptic area (VLPO) was increased after 1-2 h of recovery sleep compared with enforced waking. These results indicate state-specific effects on transcription and subsequent protein expression in cell populations associated with behavioral state and further show that the HDB, VDB and VLPO are good candidates for the further study of intracellular events associated with sleep and wakefulness. NeuroReport 11:437-440 (C) 2000 Lippincott Williams & Wilkins.
