EGF stimulates the processing and export of a secreted form of EGF receptor.
EGF stimulates the processing and export of a secreted form of EGF receptor.
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EGF 刺激分泌型 EGF 受体的加工和输出。
DOI：
10.1016/0014-5793(90)80451-n
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发表时间：
1990
期刊：
影响因子：
3.5
通讯作者：
Das,M
中科院分区：
文献类型：
--
作者：
Khire,J;Das,M
人A431细胞表达100 kDa EGF受体同系物，仅包含外部结构域。其成熟和输出的动力学是缓慢的，与跨膜受体的动力学相当。在这里，我们证明了外源性添加的EGF通过对蛋白质合成抑制剂不敏感的途径刺激该受体的翻译后加工和输出。结果表明，EGF可能会影响一个或多个控制受体从内质网出口的速率决定步骤。这可能是EGP调节其受体表达的途径之一。
Human A431 cells express a 100 kDa EGF‐receptor homolog that contains only the external domain. The kinetics of its maturation and export are slow and comparable to those of the transmembrane receptor. Here we demonstrate that exogenously added EGF stimulates post‐translational processing and export of this receptor through a pathway that is insensitive to inhibitors of protein synthesis. The results suggest that EGF may influence one or more of the rate determining steps that control receptor export from endoplasmic reticulum. This may constitute one of the path‐ways by which EGP regulates the expression of its receptor.