Egg consumption and risk of heart failure in the Physicians' Health Study
Egg consumption and risk of heart failure in the Physicians' Health Study
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DOI：
10.1161/circulationaha.107.734210
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发表时间：
2008-01-29
期刊：
影响因子：
37.8
通讯作者：
Gaziano, J. Michael
中科院分区：
文献类型：
--
作者：
Djousse, Luc;Gaziano, J. Michael
背景-降低饮食中的胆固醇被广泛推荐用于预防心血管疾病。虽然鸡蛋是饮食中胆固醇和其他营养素的重要来源，但人们对食用鸡蛋和心力衰竭(HF)风险之间的联系知之甚少。方法和结果-在一项来自医生健康研究I的21 275名参与者的前瞻性队列研究中，我们检查了鸡蛋消费和心力衰竭风险之间的关系。鸡蛋的摄入量通过一份简单的简化食物问卷进行评估，我们使用COX回归来评估心力衰竭的相对风险。经过平均20.4年的随访期，共有1084例新的心力衰竭病例发生在该队列中。尽管每周吃鸡蛋6次与心力衰竭事件无关，但每周吃7次鸡蛋会增加心力衰竭的风险。与每周食用1个鸡蛋的受试者相比，在调整了年龄、体重指数、吸烟、饮酒、运动、房颤、高血压、瓣膜心脏病和高胆固醇血症病史后，每天吃1个鸡蛋和每天吃2个鸡蛋的受试者发生心力衰竭的危险比(95%可信区间)分别为1.28(1.02至1.61)和1.64(1.08至2.49)。无心肌梗死史的心力衰竭患者也有类似的结果。结论--我们的数据表明，不经常吃鸡蛋与心力衰竭的风险无关。然而，每天食用1英镑的鸡蛋与美国男性医生患心力衰竭的风险增加有关。
Background - Reduction in dietary cholesterol is widely recommended for the prevention of cardiovascular disease. Although eggs are important sources of dietary cholesterol and other nutrients, little is known about the association between egg consumption and heart failure (HF) risk.Methods and Results - In a prospective cohort study of 21 275 participants from the Physicians' Health Study I, we examined the association between egg consumption and the risk of HF. Egg consumption was assessed with the use of a simple abbreviated food questionnaire, and we used Cox regression to estimate relative risks of HF. After an average follow-up of 20.4 years, a total of 1084 new HF cases occurred in this cohort. Although egg consumption up to 6 times per week was not associated with incident HF, egg consumption of >= 7 per week was associated with an increased risk of HF. Compared with subjects who reported egg consumption of < 1 per week, hazard ratios (95% confidence intervals) for HF were 1.28 (1.02 to 1.61) and 1.64 (1.08 to 2.49) for egg consumption of 1 per day and >= 2 per day, respectively, after adjustment for age, body mass index, smoking, alcohol consumption, exercise, and history of atrial fibrillation, hypertension, valvular heart disease, and hypercholesterolemia. Similar results were obtained for HF without antecedent myocardial infarction.Conclusions - Our data suggest that infrequent egg consumption is not associated with the risk of HF. However, egg consumption of < 1 per day is related to an increased risk of HF among US male physicians.