Formulation and Evaluation of Curcumin Gel for Topical Application
Formulation and Evaluation of Curcumin Gel for Topical Application
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DOI：
10.1080/10837450802409438
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发表时间：
2009-02-01
影响因子：
3.4
通讯作者：
Patel, Rakesh P.
中科院分区：
文献类型：
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作者：
Patel, Nikunjana A.;Patel, Natvar J.;Patel, Rakesh P.
本研究的目的是开发和研究姜黄素的局部凝胶递送，以发挥其抗炎作用。Carbopol 934 P（CRB）和羟丙基纤维素（HPC）用于制备凝胶。研究了薄荷醇（0- 12.5%w/w）对姜黄素从2%w/w CRB和HPC凝胶系统中通过离体大鼠表皮的渗透促进作用。评价所有制备的凝胶制剂的各种性质，例如相容性、药物含量、粘度、体外皮肤渗透性和抗炎作用。通过差示扫描量热法和红外光谱法证实了药物和聚合物的相容性。姜黄素通过大鼠表皮的经皮渗透通量和增强比通过添加薄荷醇到两种类型的凝胶制剂显着增强。两种类型的开发的局部凝胶制剂均无皮肤刺激。对角叉菜胶致大鼠足跖肿胀法对Wistar白化病大鼠进行抗炎实验，结果表明，CRB、HPC和标准凝胶剂的抗炎作用与对照组有显著性差异（P < 0.05），而CRB和HPC凝胶剂与标准（双氯芬酸凝胶）剂的抗炎作用无显著性差异（P > 0.05）。与HPC凝胶相比，CRB凝胶显示出更好的炎症抑制%。
The aim of the present investigation was to develop and study topical gel delivery of curcumin for its anti-inflammatory effects. Carbopol 934P (CRB) and hydroxypropylcellulose (HPC) were used for the preparation of gels. The penetration enhancing effect of menthol (0-12.5% w/w) on the percutaneous flux of curcumin through the excised rat epidermis from 2% w/w CRB and HPC gel system was investigated. All the prepared gel formulations were evaluated for various properties such as compatibility, drug content, viscosity, in vitro skin permeation, and anti-inflammatory effect. The drug and polymers compatibility wits confirmed by Differential scanning calorimetry and infrared spectroscopy. The percutaneous flux and enhancement ratio of curcumin across rat epidermis was enhanced markedly by the addition of menthol to both types of gel formulations. Both types of developed topical gel formulations were free of skin irritation. In anti-inflammatory studies done by carrageenan induced rat paw oedema method in wistar albino rats, anti-inflammatory effect of CRB, HPC and standard gel formulations were significantly different from control group (P < 0.05) whereas this effect was not significantly different for CRB and HPC gels formulations to that of standard (diclofenac gel) formulation (P > 0.05). CRB gel showed better % inhibition of inflammation as compared to HPC gel.