Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics
Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics
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DOI：
10.1364/oe.15.012277
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发表时间：
2007-09-17
期刊：
影响因子：
3.8
通讯作者：
van Leeuwen, Ton G.
中科院分区：
文献类型：
--
作者：
Manohar, Srirang;Vaartjes, Susanne E.;van Leeuwen, Ton G.
在5例有症状的乳腺患者中，有4例的感兴趣区域的近红外光声图像显示了较高强度的区域，我们将其归因于与癌症相关的血管分布。在这里介绍的2例病例中，其中一例在传统放射学图像中以良性指标为主，而光声图像显示血管特征提示恶性肿瘤，这一点得到了组织病理学的证实。结果表明，光声成像可能具有潜在的可视化某些乳腺癌的基础上固有的光学吸收对比度。该方法未来的作用可能是补充传统的乳腺成像，以帮助检测和/或诊断。(c)2007年，美国光学学会。
Near-infrared photoacoustic images of regions-of-interest in 4 of the 5 cases of patients with symptomatic breasts reveal higher intensity regions which we attribute to vascular distribution associated with cancer. Of the 2 cases presented here, one is especially significant where benign indicators dominate in conventional radiological images, while photoacoustic images reveal vascular features suggestive of malignancy, which is corroborated by histopathology. The results show that photoacoustic imaging may have potential in visualizing certain breast cancers based on intrinsic optical absorption contrast. A future role for the approach could be in supplementing conventional breast imaging to assist detection and/or diagnosis. (c) 2007 Optical Society of America.