Neocortical molecular layer heterotopia in substrains of C57BL/6 and C57BL/10 mice
Neocortical molecular layer heterotopia in substrains of C57BL/6 and C57BL/10 mice
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DOI：
10.1016/j.brainres.2011.03.026
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发表时间：
2011-05-19
期刊：
影响因子：
2.9
通讯作者：
Ramos, Raddy L.
中科院分区：
文献类型：
--
作者：
Lipoff, Danielle M.;Bhambri, Ankur;Ramos, Raddy L.
新皮质的异常发育常与认知缺陷和癫痫有关。啮齿类动物模型被广泛用于研究正常和异常的皮质发育，并揭示了许多重要的遗传和环境因素的作用。有趣的是，在行为学、解剖学和/或生理学研究中常用的几种近交系小鼠，包括C57BL/6J小鼠，都显示出新皮质畸形，这是最广泛使用的小鼠之一。在本报告中，我们描述了从三个商业供应商获得的C57BL/6J小鼠和相关品系以及从商业获得的创立者的学术试管中繁殖的小鼠的分子层异位的发生率和细胞结构。特别是，我们发现分子层异位的患病率根据小鼠的性别和来源供应商而有所不同。这些数据与使用该菌株作为研究大脑行为关系的小鼠模型有关。(C) 2011 Elsevier B.V.版权所有
Abnormal development of the neocortex is often associated with cognitive deficits and epilepsy. Rodent models are widely used to study normal and abnormal cortical development and have revealed the roles of many important genetic and environmental factors. Interestingly, several inbred mouse strains commonly used in behavioral, anatomical, and/or physiological studies display neocortical malformations including C57BL/6J mice, which are among the most widely utilized mice. In the present report we describe the prevalence and cytoarchitecture of molecular-layer heterotopia in C57BL/6J mice and related strains obtained from three commercial vendors as well as mice bred in academic vivaria from founders obtained commercially. In particular, we found that the prevalence of molecular-layer heterotopia vaired according to the sex as well as the vendor-of-origin of the mouse. These data are relevant to the use of this strain as a mouse-model in the study of brain behavior relationships. (C) 2011 Elsevier B.V. All rights reserved.