Stress Hyperglycemia in Patients With Acute Ischemic Stroke Due to Large Vessel Occlusion Undergoing Mechanical Thrombectomy.
Stress Hyperglycemia in Patients With Acute Ischemic Stroke Due to Large Vessel Occlusion Undergoing Mechanical Thrombectomy.
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DOI：
10.3389/fneur.2021.725002
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发表时间：
2021
影响因子：
3.4
通讯作者：
Valente M
中科院分区：
文献类型：
--
作者：
Merlino G;Pez S;Gigli GL;Sponza M;Lorenzut S;Surcinelli A;Smeralda C;Valente M
应激性高血糖可能损害接受机械血栓摘除术(MT)的急性缺血性中风(AIS)患者的预后。用葡萄糖/糖化血红蛋白比值(GAR)测量应激性高血糖。我们对2015年1月至2020年12月间连续入院的Udine大学医院AIS患者的数据进行了回顾分析。我们纳入了204名患者，并根据GAR的四分位数(Q1-Q4)将他们分成四组。GAR指数越高，应激性高血糖越严重。应激性高血糖越严重的患者3个月不良结局发生率(Q1，53.1%；Q2，40.4%；Q3，63.5%；Q4，82.4%；p=0.001)、3个月死亡率(Q1，14.3%；Q2，11.5%；Q3，15.4%；Q4，31.4%；p=0.001)和症状性颅内出血(Q1，2%；Q2，7.7%；Q3，7.7%；Q4，25.4%；p=0.001)。在控制了几个混杂因素后，严重应激性高血糖仍然是3个月不良预后(OR4.52，95%CI1.4-14.62，p=0.012)、3个月死亡率(OR3.55，95%CI1.02-12.29，p=0.046)和症状性颅内出血(OR6.89，95%CI1.87-25.36，p=0.004)的显著预测因素。总之，由GAR指数衡量的应激性高血糖与接受MT的AIS患者的不良影响有关。
Stress hyperglycemia may impair outcomes in patients with acute ischemic stroke (AIS) undergoing mechanical thrombectomy (MT). The glucose-to-glycated hemoglobin ratio (GAR) was used to measure stress hyperglycemia. Data from our database of consecutive patients admitted to the Udine University Hospital with AIS who were treated with MT between January 2015 and December 2020 were retrospectively analyzed. We included 204 patients in the study and stratified them into four groups according to the quartiles of GAR (Q1–Q4). The higher the GAR index, the more severe the stress hyperglycemia was considered. Patients with more severe stress hyperglycemia showed a higher prevalence of 3-month poor outcome (Q1, 53.1%; Q2, 40.4%; Q3, 63.5%; Q4, 82.4%; p = 0.001), 3-month mortality (Q1, 14.3%; Q2, 11.5%; Q3, 15.4%; Q4, 31.4%; p = 0.001), and symptomatic intracranial hemorrhage (Q1, 2%; Q2, 7.7%; Q3, 7.7%; Q4, 25.4%; p = 0.001). After controlling for several confounders, severe stress hyperglycemia remained a significant predictor of 3-month poor outcome (OR 4.52, 95% CI 1.4–14.62, p = 0.012), 3-month mortality (OR 3.55, 95% CI 1.02–12.29, p = 0.046), and symptomatic intracranial hemorrhage (OR 6.89, 95% CI 1.87–25.36, p = 0.004). In summary, stress hyperglycemia, as measured by the GAR index, is associated with a detrimental effect in patients with AIS undergoing MT.
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影响因子：
24
作者：
Elgendy, Islam Y.;Kumbhani, Dharam J.;Bavry, Anthony A.
通讯作者：
Bavry, Anthony A.
影响因子：
9.9
作者：
Bruno, A;Levine, SR;Fineberg, SE
通讯作者：
Fineberg, SE
影响因子：
158.5
作者：
Hacke, Werner;Kaste, Markku;Toni, Danilo
通讯作者：
Toni, Danilo
影响因子：
158.5
作者：
Berkhemer, O. A.;Fransen, P. S. S.;Dippel, D. W. J.
通讯作者：
Dippel, D. W. J.
影响因子：
120.7
作者：
HACKE, W;KASTE, M;HENNERICI, M
通讯作者：
HENNERICI, M