A study of twelve southern California communities with differing levels and types of air pollution - II. Effects on pulmonary function
A study of twelve southern California communities with differing levels and types of air pollution - II. Effects on pulmonary function
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DOI：
10.1164/ajrccm.159.3.9804144
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发表时间：
1999-03-01
影响因子：
24.7
通讯作者：
Thomas, DC
中科院分区：
文献类型：
--
作者：
Peters, JM;Avol, E;Thomas, DC
为了研究空气污染物可能对慢性呼吸系统产生的影响，我们设计并启动了一项为期10年的前瞻性研究，研究对象是生活在12个空气污染水平和状况不同的社区的南加州公立学校儿童。研究设计、暴露评估方法以及与呼吸道症状和状况相关的调查方法和结果见随附文件。对3，293名受试者进行了肺功能检查。根据现有监测站在1986-1990年收集的数据和我们的研究火腿在1994年收集的数据，我们评估了截面的空气污染暴露的影响。人口统计学、身体和其他环境因素与肺功能值之间存在预期关系。当按性别对数据进行分层时，发现污染水平与女性受试者肺功能降低之间存在关联，1994年接触数据的关联性强于1986-1990年数据。校正后，PM10、PM2.5和NO2均与较低的FVC、FEV 1和最大中度呼气流量（MMEF）显著相关;酸蒸汽与较低的FVC、FEV 1、峰值呼气流速（PEFR）和MMEF显著相关; O-3与较低的PEFR和MMEF显著相关。在那些花更多时间在户外的女孩中，影响通常更大。对12个社区女孩校正后的肺功能值进行逐步回归分析，结果显示，NO2与FVC较低的相关性最强PM2.5与FEV 1、O3与PEFR、MMEF的相关系数分别为-0.75，-0.80，p = 0.005。在哮喘女孩中，臭氧暴露与FVC和FEV 1降低之间存在统计学显著相关性。对于男孩来说，峰值O-3暴露与较低的FVC和FEV 1之间存在显着关联，但仅限于那些花更多时间在户外的人。这些发现强调了该队列随访的重要性。
To study the possible chronic respiratory effects of air pollutants, we designed and initiated a 10-yr prospective study of Southern California public schoolchildren living in 12 communities with different levels and profiles of air pollution. The design of the study, exposure assessment methods, and survey methods and results related to respiratory symptoms and conditions are described Tn the accompanying paper. Pulmonary function tests were completed on 3,293 subjects. We evaluated cross-sectionally the effects of air pollution exposures based on data collected in 1986-1990 by existing monitoring stations and data collected by our study ham in 1994. Expected relationships were seen between demographic, physical, and other environmental factors and pulmonary function values. When the data were stratified by sex, an association was seen between pollution levels and lower pulmonary function in female subjects, with the associations being stronger for the 1994 exposure data than the 1986-1990 data. After adjustment, PM10, PM2.5, and NO2 were each significantly associated with lower FVC, FEV1, and maximal midexpiratoyy flow (MMEF); acid vapor with lower FVC, FEV1, peak expiratory flow rate (PEFR), and MMEF; and O-3 With lower PEFR and MMEF. Effects were generally larger In those girls spending more time outdoors. Stepwise regression of adjusted pulmonary function values for girls in the 12 communities showed that NO2 was most strongly associated with lower FVC (r = -0.74, p < 0.01), PM2.5 with FEV1 (r = -0.72, p < (8.04), O-3 with PEFR (r = -0.75, p < 0.005), and PM2.5 with MMEF (r = -0.80, p < 0.005). There was a statistically significant association between ozone exposure and decreased FVC and FEV1 in girls with asthma. For boys, significant associations were seen between peak O-3 exposures and lower FVC and FEV1, but only in those spending more time outdoors. These findings underline the importance of follow-up of this cohort.