ULTRASTRUCTURAL EVIDENCE FOR HAIR CELL REGENERATION IN THE MAMMALIAN INNER-EAR
ULTRASTRUCTURAL EVIDENCE FOR HAIR CELL REGENERATION IN THE MAMMALIAN INNER-EAR
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DOI：
10.1126/science.8456284
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发表时间：
1993-03-12
期刊：
影响因子：
56.9
通讯作者：
NEVILL, G
中科院分区：
文献类型：
--
作者：
FORGE, A;LI, L;NEVILL, G
长期以来，人们一直认为哺乳动物内耳的毛细胞损失是不可逆转的。该报告提供了豚鼠内耳椭圆囊的扫描电子显微照片和薄片，显示在氨基糖苷类庆大霉素治疗导致毛细胞损失后，毛细胞重新出现。治疗结束4周后，在椭圆囊中可以发现大量具有多个发育阶段的未成熟毛束的细胞。薄切片显示丢失的 1 型毛细胞被形态与 2 型毛细胞相似的细胞所取代。这些结果表明成熟哺乳动物内耳具有意想不到的体内毛细胞再生能力。
It has long been thought that hair cell loss from the inner ears of mammals is irreversible. This report presents scanning electron micrographs and thin sections of the utricles from the inner ears of guinea pigs that show that, after hair cell loss caused by treatment with the aminoglycoside gentamicin, hair cells reappeared. Four weeks after the end of treatment, a large number of cells with immature hair bundles in multiple stages of development could be identified in the utricle. Thin sections showed that lost type 1 hair cells were replaced by cells with a morphology similar to that of type 2 hair cells. These results indicate an unexpected capacity for hair cell regeneration in vivo in the mature mammalian inner ear.